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Risk Factors
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2023
Gao XRaymond
,
Chiariglione M
,
Qin K
,
Nuytemans K
,
Scharre DW
,
Li Y-J
,
Martin ER
. 2023.
Explainable machine learning aggregates polygenic risk scores and electronic health records for Alzheimer's disease prediction.
.
Sci Rep. 13(1):450.
2022
Holstege H
,
Hulsman M
,
Charbonnier C
,
Grenier-Boley B
,
Quenez O
,
Grozeva D
,
van Rooij JGJ
,
Sims R
,
Ahmad S
,
Amin N
et al.
. 2022.
Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease.
.
Nat Genet. 54(12):1786-1794.
Rajabli F
,
Beecham GW
,
Hendrie HC
,
Baiyewu O
,
Ogunniyi A
,
Gao S
,
Kushch NA
,
Lipkin-Vasquez M
,
Hamilton-Nelson KL
,
Young JI
et al.
. 2022.
A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry.
.
PLoS Genet. 18(7):e1009977.
2018
Rajabli F
,
Feliciano BE
,
Celis K
,
Hamilton-Nelson KL
,
Whitehead PL
,
Adams LD
,
Bussies PL
,
Manrique CP
,
Rodriguez A
,
Rodriguez V
et al.
. 2018.
Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations.
.
PLoS Genet. 14(12):e1007791.
Bonham LW
,
Karch CM
,
Fan CC
,
Tan C
,
Geier EG
,
Wang Y
,
Wen N
,
Broce IJ
,
Li Y
,
Barkovich MJ
et al.
. 2018.
CXCR4 involvement in neurodegenerative diseases.
.
Transl Psychiatry. 8(1):73.
Lancour D
,
Naj A
,
Mayeux R
,
Haines JL
,
Pericak-Vance MA
,
Schellenberg GD
,
Crovella M
,
Farrer LA
,
Kasif S
. 2018.
One for all and all for One: Improving replication of genetic studies through network diffusion.
.
PLoS Genet. 14(4):e1007306.
2017
Huang K-L
,
Marcora E
,
Pimenova AA
,
Di Narzo AF
,
Kapoor M
,
Jin SChih
,
Harari O
,
Bertelsen S
,
Fairfax BP
,
Czajkowski J
et al.
. 2017.
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.
.
Nat Neurosci. 20(8):1052-1061.
Kunkle BW
,
Vardarajan BN
,
Naj AC
,
Whitehead PL
,
Rolati S
,
Slifer S
,
Carney RM
,
Cuccaro ML
,
Vance JM
,
Gilbert JR
et al.
. 2017.
Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport.
.
JAMA Neurol. 74(9):1113-1122.
Deming Y
,
Li Z
,
Kapoor M
,
Harari O
,
Del-Aguila JL
,
Black K
,
Carrell D
,
Cai Y
,
Fernandez MVictoria
,
Budde J
et al.
. 2017.
Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.
.
Acta Neuropathol. 133(5):839-856.
Tan CHong
,
Hyman BT
,
Tan JJX
,
Hess CP
,
Dillon WP
,
Schellenberg GD
,
Besser LM
,
Kukull WA
,
Kauppi K
,
McEvoy LK
et al.
. 2017.
Polygenic hazard scores in preclinical Alzheimer disease.
.
Ann Neurol. 82(3):484-488.
Ighodaro ET
,
Abner EL
,
Fardo DW
,
Lin A-L
,
Katsumata Y
,
Schmitt FA
,
Kryscio RJ
,
Jicha GA
,
Neltner JH
,
Monsell SE
et al.
. 2017.
Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals.
.
J Cereb Blood Flow Metab. 37(1):201-216.
Yokoyama JS
,
Karch CM
,
Fan CC
,
Bonham LW
,
Kouri N
,
Ross OA
,
Rademakers R
,
Kim J
,
Wang Y
,
Höglinger GU
et al.
. 2017.
Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia.
.
Acta Neuropathol. 133(5):825-837.
2016
Karch CM
,
Ezerskiy LA
,
Bertelsen S
,
Goate AM
. 2016.
Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.
.
PLoS One. 11(2):e0148717.
Ebbert MTW
,
Boehme KL
,
Wadsworth ME
,
Staley LA
,
Mukherjee S
,
Crane PK
,
Ridge PG
,
Kauwe JSK
. 2016.
Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk.
.
Alzheimers Dement. 12(2):121-129.
2015
Østergaard SD
,
Mukherjee S
,
Sharp SJ
,
Proitsi P
,
Lotta LA
,
Day F
,
Perry JRB
,
Boehme KL
,
Walter S
,
Kauwe JS
et al.
. 2015.
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.
.
PLoS Med. 12(6):e1001841;discussione1001841.
Mukherjee S
,
Walter S
,
Kauwe JSK
,
Saykin AJ
,
Bennett DA
,
Larson EB
,
Crane PK
,
M Glymour M
. 2015.
Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses.
.
Alzheimers Dement. 11(12):1439-1451.
Desikan RS
,
Schork AJ
,
Wang Y
,
Thompson WK
,
Dehghan A
,
Ridker PM
,
Chasman DI
,
McEvoy LK
,
Holland D
,
Chen C-H
et al.
. 2015.
Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.
.
Circulation. 131(23):2061-2069.
Nelson PT
,
Wang W-X
,
Partch AB
,
Monsell SE
,
Valladares O
,
Ellingson SR
,
Wilfred BR
,
Naj AC
,
Wang L-S
,
Kukull WA
et al.
. 2015.
Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology.
.
J Neuropathol Exp Neurol. 74(1):75-84.
2014
Naj AC
,
Jun G
,
Reitz C
,
Kunkle BW
,
Perry W
,
Park YSon
,
Beecham GW
,
Rajbhandary RA
,
Hamilton-Nelson KL
,
Wang L-S
et al.
. 2014.
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
.
JAMA Neurol. 71(11):1394-404.
2013
Tsuang D
,
Leverenz JB
,
Lopez OL
,
Hamilton RL
,
Bennett DA
,
Schneider JA
,
Buchman AS
,
Larson EB
,
Crane PK
,
Kaye JA
et al.
. 2013.
APOE ε4 increases risk for dementia in pure synucleinopathies.
.
JAMA Neurol. 70(2):223-8.
Nuytemans K
,
Bademci G
,
Kohli MM
,
Beecham GW
,
Wang L-S
,
Young JI
,
Nahab F
,
Martin ER
,
Gilbert JR
,
Benatar M
et al.
. 2013.
C9ORF72 intermediate repeat copies are a significant risk factor for Parkinson disease.
.
Ann Hum Genet. 77(5):351-63.
McDavid A
,
Crane PK
,
Newton KM
,
Crosslin DR
,
McCormick W
,
Weston N
,
Ehrlich K
,
Hart E
,
Harrison R
,
Kukull WA
et al.
. 2013.
Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records.
.
PLoS One. 8(6):e63481.
Cruchaga C
,
Kauwe JSK
,
Harari O
,
Jin SChih
,
Cai Y
,
Karch CM
,
Benitez BA
,
Jeng AT
,
Skorupa T
,
Carrell D
et al.
. 2013.
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
.
Neuron. 78(2):256-68.
Reitz C
,
Tosto G
,
Vardarajan B
,
Rogaeva E
,
Ghani M
,
Rogers RS
,
Conrad C
,
Haines JL
,
Pericak-Vance MA
,
Fallin MD
et al.
. 2013.
Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP).
.
Transl Psychiatry. 3:e256.
Holton P
,
Ryten M
,
Nalls M
,
Trabzuni D
,
Weale ME
,
Hernandez D
,
Crehan H
,
J Gibbs R
,
Mayeux R
,
Haines JL
et al.
. 2013.
Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.
.
Ann Hum Genet. 77(2):85-105.
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