Alzheimer's Disease
Genetics Consortium

ADGC Publications

Found 77 results

Filters: Author is Farrer, Lindsay A [Clear All Filters]

2015

Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen C-H et al.. 2015. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.. Circulation. 131(23):2061-2069.

Nho K, Kim S, Risacher SL, Shen L, Corneveaux JJ, Swaminathan S, Lin H, Ramanan VK, Liu Y, Foroud TM et al.. 2015. Protective variant for hippocampal atrophy identified by whole exome sequencing.. Ann Neurol. 77(3):547-52.

Wang L-S, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JDGonzalez, Cannon-Albright L, Baldwin CT, Zetterberg H et al.. 2015. Rarity of the Alzheimer disease-protective APP A673T variant in the United States.. JAMA Neurol. 72(2):209-16.

2014

Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang W-X, Wilfred BR, Wang L-S et al.. 2014. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.. Acta Neuropathol. 127(6):825-43.

Allen M, Kachadoorian M, Quicksall Z, Zou F, Chai HSeng, Younkin C, Crook JE, V Pankratz S, Carrasquillo MM, Krishnan S et al.. 2014. Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels.. Alzheimers Res Ther. 6(4):39.

Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YSon, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang L-S et al.. 2014. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.. JAMA Neurol. 71(11):1394-404.

Escott-Price V, Bellenguez C, Wang L-S, Choi S-H, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A et al.. 2014. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.. PLoS One. 9(6):e94661.

Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel J-P, Younkin SG et al.. 2014. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.. PLoS Genet. 10(9):e1004606.

Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, De Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A et al.. 2014. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.. Alzheimers Dement. 10(1):45-52.

Benitez BA, Jin SChih, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert J-C, J Gibbs R, Bras J et al.. 2014. Missense variant in TREML2 protects against Alzheimer's disease.. Neurobiol Aging. 35(6):1510.e19-26.

Jun G, Asai H, Zeldich E, Drapeau E, Chen CD, Chung J, Park J-H, Kim S, Haroutunian V, Foroud T et al.. 2014. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.. Ann Neurol. 76(3):379-92.

Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W et al.. 2014. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.. Nat Med. 20(12):1452-7.

Logue MW, Schu M, Vardarajan BN, Farrell J, Lunetta KL, Jun G, Baldwin CT, Deangelis MM, Farrer LA. 2014. Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways.. Neurobiol Aging. 35(6):1510.e7-18.

2013

Cruchaga C, Kauwe JSK, Harari O, Jin SChih, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D et al.. 2013. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.. Neuron. 78(2):256-68.

Holton P, Ryten M, Nalls M, Trabzuni D, Weale ME, Hernandez D, Crehan H, J Gibbs R, Mayeux R, Haines JL et al.. 2013. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.. Ann Hum Genet. 77(2):85-105.

Miyashita A, Koike A, Jun G, Wang L-S, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H et al.. 2013. SORL1 Is Genetically Associated with Late-Onset Alzheimer's Disease in Japanese, Koreans and Caucasians.. PLoS One. 8(4):e58618.

Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BNarayan, Wang L-S, Valladares O, Lin C-F, Larson EB, Graff-Radford NR et al.. 2013. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.. JAMA. 309(14):1483-92.

2012

Zou F, Chai HSeng, Younkin CS, Allen M, Crook J, V Pankratz S, Carrasquillo MM, Rowley CN, Nair AA, Middha S et al.. 2012. Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.. PLoS Genet. 8(6):e1002707.

Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS et al.. 2012. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.. Nat Genet. 44(12):1349-54.

Jun G, Vardarajan BN, Buros J, Yu C-E, Hawk MV, Dombroski BA, Crane PK, Larson EB, Mayeux R, Haines JL et al.. 2012. Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.. Arch Neurol. 69(10):1270-9.

Coppola G, Chinnathambi S, Lee JJiYong, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R et al.. 2012. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.. Hum Mol Genet. 21(15):3500-12.

Vardarajan BN, Bruesegem SY, Harbour ME, Inzelberg R, Friedland R, St George-Hyslop P, Seaman MNJ, Farrer LA. 2012. Identification of Alzheimer disease-associated variants in genes that regulate retromer function.. Neurobiol Aging. 33(9):2231.e15-2231.e30.

Allen M, Zou F, Chai HSeng, Younkin CS, Crook J, V Pankratz S, Carrasquillo MM, Rowley CN, Nair AA, Middha S et al.. 2012. Novel late-onset Alzheimer disease loci variants associate with brain gene expression.. Neurology. 79(3):221-8.

2011

Naj AC, Jun G, Beecham GW, Wang L-S, Vardarajan BNarayan, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK et al.. 2011. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.. Nat Genet. 43(5):436-41.

Jun G, Buros J, Vardarajan BNarayan, Lunetta KL, Farrer LA. 2011. Genome-wide scan suggested novel Alzheimer disease susceptibility genes by factoring influence of APOE. ASHG/ICHG 2011 (Montreal, Canada).

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