ADGC Announcements

ADGC Request for Analysis Proposals

August 2010


NIA Alzheimers Disease Centers Request for Samples

August 2010

Once again we wish to thank all of the ADCs that have participated in the Alzheimer's Disease
Genetics Consortium (ADGC) by contributing brain tissue and DNA for GWAS studies. For the
next phase of the study the ADGC is ready to launch an initiative to collect blood samples
from ADC patients who have received the UDS and are diagnosed with possible or probable
AD (NINCDS-ADRDA criteria) as well as blood from cognitively normal individuals, for deposit
at NCRAD. NACC will provide a list of eligible patients for each Center on the NACC
website ( ).
Upon receipt of an eligible blood sample,
shipped according to the instructions (see attached) using the NCRAD sample form, NCRAD
will extract DNA for the ADGC and provide DNA back to the Center if requested.

The ADGC will reimburse $75 per eligible sample received at NCRAD, and provide genotypes back to
each ADC, including genome-wide associated ApoE, PICALM, CR1, CLU, and others.

The ADGC is making great strides with your help and the NIA asks that you continue to support
them by providing the blood samples from patients and cognitively normal individuals enrolled
and receiving the UDS in your Centers.


Blood_initiative_instructions_8 3 2010-kf.doc

Creighton H. Phelps, Ph.D.
Alzheimer's Disease Centers Program
Division of Neuroscience
National Institute on Aging
National Institutes of Health

MOU and Analysis Proposal Forms Approved by the Executive Committee

September 25, 2009

Memorandum of Understanding (MOU) form and Analysis Proposal Guidelines have been approved by
the ADGC committee and is now on the ADGC website for members to access.

To acquire access to the ADGC datasets, the applicant should
(1) be an ADGC member, (2) submit the completed MOU form (signed by the applicant's institution)
and an analysis proposal (maximum two pages, following the proposal guidelines)
to be reviewed by the ADGC executive committee. Please contact Laura Cantwell (Contact Information) for details.