- Home
- About
- Collaborative Data Access (SAGs)
- Publications
- For Members
Title | Assessment of the genetic variance of late-onset Alzheimer's disease. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Kauwe JSK |
Corporate Authors | Alzheimer's Disease Genetics Consortium(ADGC) |
Journal | Neurobiol Aging |
Volume | 41 |
Pagination | 200.e13-200.e20 |
Date Published | 2016 May |
ISSN | 1558-1497 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Protein Precursor, Datasets as Topic, Female, Genetic Variation, Genome-Wide Association Study, Humans, Male, Membrane Glycoproteins, Netrin Receptors, Polymorphism, Single Nucleotide, Receptors, Cell Surface, Receptors, Immunologic, Risk |
Abstract | Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. More than 20 common markers have been identified, which are associated with AD. Recently, several rare variants have been identified in Amyloid Precursor Protein (APP), Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) and Unc-5 Netrin Receptor C (UNC5C) that affect risk for AD. Despite the many successes, the genetic architecture of AD remains unsolved. We used Genome-wide Complex Trait Analysis to (1) estimate phenotypic variance explained by genetics; (2) calculate genetic variance explained by known AD single nucleotide polymorphisms (SNPs); and (3) identify the genomic locations of variation that explain the remaining unexplained genetic variance. In total, 53.24% of phenotypic variance is explained by genetics, but known AD SNPs only explain 30.62% of the genetic variance. Of the unexplained genetic variance, approximately 41% is explained by unknown SNPs in regions adjacent to known AD SNPs, and the remaining unexplained genetic variance outside these regions. |
DOI | 10.1016/j.neurobiolaging.2016.02.024 |
Alternate Journal | Neurobiol. Aging |
PubMed ID | 27036079 |
PubMed Central ID | PMC4948179 |
Grant List | P30 AG013854 / AG / NIA NIH HHS / United States P50 MH060451 / MH / NIMH NIH HHS / United States MH60451 / MH / NIMH NIH HHS / United States UL1 TR001445 / TR / NCATS NIH HHS / United States R01 AG022374 / AG / NIA NIH HHS / United States P30 AG010124 / AG / NIA NIH HHS / United States P50 AG023501 / AG / NIA NIH HHS / United States R01 AG17917 / AG / NIA NIH HHS / United States U01 HG006375 / HG / NHGRI NIH HHS / United States M01 RR000096 / RR / NCRR NIH HHS / United States RC2 AG036528 / AG / NIA NIH HHS / United States AG041232 / AG / NIA NIH HHS / United States P30 AG028377 / AG / NIA NIH HHS / United States RF1 AG015819 / AG / NIA NIH HHS / United States AG07562 / AG / NIA NIH HHS / United States P50 AG008671 / AG / NIA NIH HHS / United States P50 AG005142 / AG / NIA NIH HHS / United States U01 AG10483 / AG / NIA NIH HHS / United States P30 AG10133 / AG / NIA NIH HHS / United States R01 AG035137 / AG / NIA NIH HHS / United States P50 AG005131 / AG / NIA NIH HHS / United States P50 AG005128 / AG / NIA NIH HHS / United States P30 AG010133 / AG / NIA NIH HHS / United States U24 AG021886 / AG / NIA NIH HHS / United States R01 AG031581 / AG / NIA NIH HHS / United States R01AG042611 / AG / NIA NIH HHS / United States P50 AG016574 / AG / NIA NIH HHS / United States P50 AG005146 / AG / NIA NIH HHS / United States R01 AG019085 / AG / NIA NIH HHS / United States U01 AG032984 / AG / NIA NIH HHS / United States U01 HG008657 / HG / NHGRI NIH HHS / United States R01 AG042611 / AG / NIA NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States R01 AG030146 / AG / NIA NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States AG02365 / AG / NIA NIH HHS / United States P50 AG008702 / AG / NIA NIH HHS / United States UL1 RR029893 / RR / NCRR NIH HHS / United States / / Medical Research Council / United Kingdom AG05128 / AG / NIA NIH HHS / United States U01 AG016976 / AG / NIA NIH HHS / United States P50 NS039764 / NS / NINDS NIH HHS / United States P01 AG003991 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States P50 AG005681 / AG / NIA NIH HHS / United States P30 AG013846 / AG / NIA NIH HHS / United States RC2 AG036502 / AG / NIA NIH HHS / United States R01 AG017917 / AG / NIA NIH HHS / United States 1R01AG035137 / AG / NIA NIH HHS / United States U24-AG041689-01 / AG / NIA NIH HHS / United States R01 MH080295 / MH / NIMH NIH HHS / United States P01 AG03991 / AG / NIA NIH HHS / United States P50 AG005136 / AG / NIA NIH HHS / United States AG010491 / AG / NIA NIH HHS / United States P30 AG08051 / AG / NIA NIH HHS / United States P30 AG012300 / AG / NIA NIH HHS / United States AG041718 / AG / NIA NIH HHS / United States P50AG016574 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States P50 AG016573 / AG / NIA NIH HHS / United States 5R01AG022374 / AG / NIA NIH HHS / United States U24 AG041689 / AG / NIA NIH HHS / United States P01 AG019724 / AG / NIA NIH HHS / United States P50 AG016570 / AG / NIA NIH HHS / United States P50 AG005134 / AG / NIA NIH HHS / United States P30 AG008017 / AG / NIA NIH HHS / United States R01AG33193 / AG / NIA NIH HHS / United States P30 AG010161 / AG / NIA NIH HHS / United States R01 AG15819 / AG / NIA NIH HHS / United States R01 AG033193 / AG / NIA NIH HHS / United States 1RC2AG036502 / AG / NIA NIH HHS / United States M01RR00096 / RR / NCRR NIH HHS / United States AG030653 / AG / NIA NIH HHS / United States AG025688 / AG / NIA NIH HHS / United States AG027944 / AG / NIA NIH HHS / United States P50 AG025688 / AG / NIA NIH HHS / United States R37 AG015473 / AG / NIA NIH HHS / United States U24 AG026395 / AG / NIA NIH HHS / United States AG05144 / AG / NIA NIH HHS / United States R01 CA129769 / CA / NCI NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States U01 AG010483 / AG / NIA NIH HHS / United States P01 AG002219 / AG / NIA NIH HHS / United States U01 AG006781 / AG / NIA NIH HHS / United States R01 AG041797 / AG / NIA NIH HHS / United States P50 AG005144 / AG / NIA NIH HHS / United States P01 AG010491 / AG / NIA NIH HHS / United States R01 AG021547 / AG / NIA NIH HHS / United States R01 AG041232 / AG / NIA NIH HHS / United States P50 AG005138 / AG / NIA NIH HHS / United States R01 AG019757 / AG / NIA NIH HHS / United States R01 AG020688 / AG / NIA NIH HHS / United States 5R01AG012101 / AG / NIA NIH HHS / United States R01 AG030653 / AG / NIA NIH HHS / United States R01 AG027944 / AG / NIA NIH HHS / United States R01 AG30146 / AG / NIA NIH HHS / United States R01 AG017173 / AG / NIA NIH HHS / United States R01 AG025259 / AG / NIA NIH HHS / United States U01 HG004610 / HG / NHGRI NIH HHS / United States P30 AG010129 / AG / NIA NIH HHS / United States P30 AG019610 / AG / NIA NIH HHS / United States NS39764, / NS / NINDS NIH HHS / United States P50 AG016582 / AG / NIA NIH HHS / United States R01 AG041718 / AG / NIA NIH HHS / United States 5R01AG013616 / AG / NIA NIH HHS / United States P30 AG028383 / AG / NIA NIH HHS / United States AG019757 / AG / NIA NIH HHS / United States R01AG041797 / AG / NIA NIH HHS / United States R01 AG026916 / AG / NIA NIH HHS / United States P50 AG033514 / AG / NIA NIH HHS / United States R01 NS059873 / NS / NINDS NIH HHS / United States AG021547 / AG / NIA NIH HHS / United States UL1RR02777 / RR / NCRR NIH HHS / United States R01 AG015819 / AG / NIA NIH HHS / United States IK2 BX001820 / BX / BLRD VA / United States |