Statin users without an APOE-epsilon4 allele have increased insulin resistance.

TitleStatin users without an APOE-epsilon4 allele have increased insulin resistance.
Publication TypeJournal Article
Year of Publication2010
AuthorsVanFossen BT, G Watson S, Baker LD, Rhoads KW, Cholerton BA, Reger MA, Plymate SR, Schellenberg G, Craft S
JournalJ Alzheimers Dis
Volume19
Issue4
Pagination1149-53
Date Published2010
ISSN1875-8908
KeywordsAged, Alzheimer Disease, Anticholesteremic Agents, Apolipoprotein E4, Dementia, Diabetes Mellitus, Female, Genotype, Homeostasis, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Male, Metabolic Syndrome, Prevalence
Abstract

The present study examined the relationships among statin use, APOE genotype, and insulin resistance as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) in healthy older adults. APOE epsilon4- (i.e., not having an epsilon4 allele) statin users had higher HOMA-IR values compared with epsilon4+/statin users (p=0.0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE epsilon4 allele.
DOI10.3233/JAD-2010-1319
Alternate JournalJ. Alzheimers Dis.
PubMed ID20308781
PubMed Central IDPMC2945621
Grant ListR37AG010880 / AG / NIA NIH HHS / United States
K01 AG023640 / AG / NIA NIH HHS / United States
T32 AG000258 / AG / NIA NIH HHS / United States
K01 AG023640-05 / AG / NIA NIH HHS / United States
R37 AG010880 / AG / NIA NIH HHS / United States
T32 AG000258-11 / AG / NIA NIH HHS / United States
K01AG23640 / AG / NIA NIH HHS / United States
R37 AG010880-17 / AG / NIA NIH HHS / United States