Alzheimer's Disease
Genetics Consortium

ADGC Publications

Found 78 results

Filters: Keyword is Genome-Wide Association Study [Clear All Filters]

2015

Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen C-H et al.. 2015. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.. Circulation. 131(23):2061-2069.

2014

Barral S, Cosentino S, Christensen K, Newman AB, Perls TT, Province MA, Mayeux R. 2014. Common genetic variants on 6q24 associated with exceptional episodic memory performance in the elderly.. JAMA Neurol. 71(12):1514-9.

Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YSon, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang L-S et al.. 2014. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.. JAMA Neurol. 71(11):1394-404.

McMillan CT, Toledo JB, Avants BB, Cook PA, Wood EM, Suh ER, Irwin DJ, Powers J, Olm C, Elman L et al.. 2014. Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration.. Neurobiol Aging. 35(6):1473-82.

Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel J-P, Younkin SG et al.. 2014. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.. PLoS Genet. 10(9):e1004606.

Kauwe JSK, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C et al.. 2014. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.. PLoS Genet. 10(10):e1004758.

Jun G, Asai H, Zeldich E, Drapeau E, Chen CD, Chung J, Park J-H, Kim S, Haroutunian V, Foroud T et al.. 2014. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.. Ann Neurol. 76(3):379-92.

Logue MW, Schu M, Vardarajan BN, Farrell J, Lunetta KL, Jun G, Baldwin CT, Deangelis MM, Farrer LA. 2014. Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways.. Neurobiol Aging. 35(6):1510.e7-18.

Ramirez A, van der Flier WM, Herold C, Ramonet D, Heilmann S, Lewczuk P, Popp J, Lacour A, Drichel D, Louwersheimer E et al.. 2014. SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.. Hum Mol Genet. 23(24):6644-58.

Logue MW, Schu M, Vardarajan BN, Farrell J, Bennett DA, Buxbaum JD, Byrd GS, Ertekin-Taner N, Evans D, Foroud T et al.. 2014. Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans.. Alzheimers Dement. 10(6):609-618.e11.

2013

Lin C-F, Naj AC, Wang L-S. 2013. Analyzing copy number variation using SNP array data: protocols for calling CNV and association tests.. Curr Protoc Hum Genet. 79:Unit1.27..

McDavid A, Crane PK, Newton KM, Crosslin DR, McCormick W, Weston N, Ehrlich K, Hart E, Harrison R, Kukull WA et al.. 2013. Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records.. PLoS One. 8(6):e63481.

Hibar DP, Stein JL, Ryles AB, Kohannim O, Jahanshad N, Medland SE, Hansell NK, McMahon KL, de Zubicaray GI, Montgomery GW et al.. 2013. Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.. Brain Imaging Behav. 7(2):102-15.

Cruchaga C, Kauwe JSK, Harari O, Jin SChih, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D et al.. 2013. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.. Neuron. 78(2):256-68.

Holton P, Ryten M, Nalls M, Trabzuni D, Weale ME, Hernandez D, Crehan H, J Gibbs R, Mayeux R, Haines JL et al.. 2013. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.. Ann Hum Genet. 77(2):85-105.

Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B et al.. 2013. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.. Nat Genet. 45(12):1452-8.

Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BNarayan, Wang L-S, Valladares O, Lin C-F, Larson EB, Graff-Radford NR et al.. 2013. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.. JAMA. 309(14):1483-92.

2012

Zou F, Chai HSeng, Younkin CS, Allen M, Crook J, V Pankratz S, Carrasquillo MM, Rowley CN, Nair AA, Middha S et al.. 2012. Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.. PLoS Genet. 8(6):e1002707.

Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS et al.. 2012. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.. Nat Genet. 44(12):1349-54.

Barral S, Bird T, Goate A, Farlow MR, Diaz-Arrastia R, Bennett DA, Graff-Radford N, Boeve BF, Sweet RA, Stern Y et al.. 2012. Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.. Neurology. 78(19):1464-71.

Vardarajan BN, Bruesegem SY, Harbour ME, Inzelberg R, Friedland R, St George-Hyslop P, Seaman MNJ, Farrer LA. 2012. Identification of Alzheimer disease-associated variants in genes that regulate retromer function.. Neurobiol Aging. 33(9):2231.e15-2231.e30.

Ramanan VK, Shen L, Moore JH, Saykin AJ. 2012. Pathway analysis of genomic data: concepts, methods, and prospects for future development.. Trends Genet. 28(7):323-32.

2011

Naj AC, Jun G, Beecham GW, Wang L-S, Vardarajan BNarayan, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK et al.. 2011. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.. Nat Genet. 43(5):436-41.

Höglinger GU, Melhem NM, Dickson DW, Sleiman PMA, San Wang L-, Klei L, Rademakers R, de Silva R, Litvan I, Riley DE et al.. 2011. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.. Nat Genet. 43(7):699-705.

Sherva R, Farrer LA. 2011. Power and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease.. Curr Psychiatry Rep. 13(2):138-46.

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