Publications Using ADGC Supported Studies

2020

Pathak GA, Zhou Z, Silzer TK, Barber RC, Phillips NR; Alzheimer's Disease Neuroimaging Initiative, Breast and Prostate Cancer Cohort Consortium, and Alzheimer's Disease Genetics Consortium. Two-stage Bayesian GWAS of 9576 individuals identifies SNP regions that are targeted by miRNAs inversely expressed in Alzheimer's and cancer. Alzheimers Dement. 2020 Jan;16(1):162-177. doi: 10.1002/alz.12003.PMID:31914222

2019

Ji Z, Liao Y, Zheng L, Wu L, Yu M, Feng Y. An Assembled Detector Based on Geometrical Constraint for Power Component Recognition. Sensors (Basel). 2019 Aug 11;19(16). pii: E3517. doi: 10.3390/s19163517. PMID: 31405244

2018

Mukherjee S, Mez J, Trittschuh EH, Saykin AJ, Gibbons LE, Fardo DW, Wessels M, Bauman J, Moore M, Choi SE, Gross AL, Rich J, Louden DKN, Sanders RE, Grabowski TJ, Bird TD, McCurry SM, Snitz BE, Kamboh MI, Lopez OL, De Jager PL, Bennett DA, Keene CD, Larson EB; EPAD Study Group; Investigators from ACT; Investigators from ROS; Investigators from MAP; Investigators from ADNI; Investigators from the University of Pittsburgh ADRC, Crane PK. Genetic Data and Cognitively Defined Late-onset Alzheimer's Disease Subgroups. Mol Psychiatry. 2018 Dec 4. doi: 10.1038/s41380-018-0298-8. PMCID: PMC6548676. PMID: 30514930

Dobbyn A, Huckins LM, Boocock J, Sloofman LG, Glicksberg BS, Giambartolomei C, Hoffman GE, Perumal TM, Girdhar K, Jiang Y, Raj T, Ruderfer DM, Kramer RS, Pinto D; CommonMind Consortium, Akbarian S, Roussos P, Domenici E, Devlin B, Sklar P, Stahl EA, Sieberts SK. Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS. Am J Hum Genet. 2018 Jun 7;102(6):1169-1184. doi: 10.1016/j.ajhg.2018.04.011. Epub 2018 May 24. PMCID: PMC5993513. PMID: 29805045

Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol. 2018 Jun;13(2):254-264. doi: 10.1007/s11481-018-9781-x. Epub 2018 Mar 7. PMCID: PMC5928172. PMID: 29516269

Zhou X, Chen Y, Mok KY, Zhao Q, Chen K, Chen Y, Hardy J, Li Y, Fu AKY, Guo Q, Ip NY; Alzheimer’s Disease Neuroimaging Initiative. Identification of Genetic Risk Factors in the Chinese Population Implicates a Role of Immune System in Alzheimer's Disease Pathogenesis. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1697-1706. doi: 10.1073/pnas.1715554115. Epub 2018 Feb 5. PMCID: PMC5828602. PMID: 29432188

Bennett RE, Robbins AB, Hu M, Cao X, Betensky RA, Clark T, Das S, Hyman BT. Tau Induces Blood Vessel Abnormalities and Angiogenesis-related Gene Expression in P301L Transgenic Mice and Human Alzheimer's Disease. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1289-E1298. doi: 10.1073/pnas.1710329115. Epub 2018 Jan 22.PMCID: PMC5819390. PMID: 29358399

2017

Miller JA, Guillozet-Bongaarts A, Gibbons LE, Postupna N, Renz A, Beller AE, Sunkin SM, Ng L, Rose SE, Smith KA, Szafer A, Barber C, Bertagnolli D, Bickley K, Brouner K, Caldejon S, Chapin M, Chua ML, Coleman NM, Cudaback E, Cuhaciyan C, Dalley RA, Dee N, Desta T, Dolbeare TA, Dotson NI, Fisher M, Gaudreault N, Gee G, Gilbert TL, Goldy J, Griffin F, Habel C, Haradon Z, Hejazinia N, Hellstern LL, Horvath S, Howard K, Howard R, Johal J, Jorstad NL, Josephsen SR, Kuan CL, Lai F, Lee E, Lee F, Lemon T, Li X, Marshall DA, Melchor J, Mukherjee S, Nyhus J, Pendergraft J, Potekhina L, Rha EY, Rice S, Rosen D, Sapru A, Schantz A, Shen E, Sherfield E, Shi S, Sodt AJ, Thatra N, Tieu M, Wilson AM, Montine TJ, Larson EB, Bernard A, Crane PK, Ellenbogen RG, Keene CD, Lein E. Neuropathological and Transcriptomic Characteristics of the Aged Brain. Elife. 2017 Nov 9;6. pii: e31126. doi: 10.7554/eLife.31126. PMCID: PMC5679757. PMID: 29120328

Larsson SC, Markus HS. Branched-chain Amino Acids and Alzheimer's Disease: a Mendelian Randomization Analysis. Sci Rep. 2017 Oct 19;7(1):13604. doi: 10.1038/s41598-017-12931-1. PMCID: PMC5648806. PMID: 29051501

Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Karaca I, Naj A, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Ramirez A, Scherer M, Farrer LA, Haines JL, Pericak-Vance MA, Raskind WH, Cruchaga C, Schellenberg GD, Joseph B, Brkanac Z. Caspase-8, Association with Alzheimer's Disease and Functional Analysis of Rare Variants. PLoS One. 2017 Oct 6;12(10):e0185777. doi: 10.1371/journal.pone.0185777. eCollection 2017. PMCID: PMC5630132. PMID: 28985224

Sennik S, Schweizer TA, Fischer CE, Munoz DG. Risk Factors and Pathological Substrates Associated with Agitation/Aggression in Alzheimer's Disease: A Preliminary Study using NACC Data. J Alzheimers Dis. 2017;55(4):1519-1528. doi: 10.3233/JAD-160780. PMCID: PMC5607738. PMID: 27911311

LoBue C, Wadsworth H, Wilmoth K, Clem M, Hart J Jr, Womack KB, Didehbani N, Lacritz LH, Rossetti HC, Cullum CM. Traumatic Brain Injury History is Associated with Earlier Age of Onset of Alzheimer Disease. Clin Neuropsychol. 2017 Jan;31(1):85-98. doi: 10.1080/13854046.2016.1257069. Epub 2016 Nov 18. PMCID: PMC5224912. PMID: 27855547

2016

Deming Y, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Huang KL, Sutphen CL, Tarawneh R, Fagan AM, Holtzman DM, Morris JC, Goate AM, Dougherty JD, Cruchaga C. Chitinase-3-like 1 Protein (CHI3L1) Locus Influences Cerebrospinal Fluid Levels of YKL-40. BMC Neurol. 2016 Nov 10;16(1):217.PMCID: PMC5105244. PMID: 27832767

Kenna KP, van Doormaal PT, Dekker AM, Ticozzi N, Kenna BJ, Diekstra FP, van Rheenen W, van Eijk KR, Jones AR, Keagle P, Shatunov A, Sproviero W, Smith BN, van Es MA, Topp SD, Kenna A, Miller JW, Fallini C, Tiloca C, McLaughlin RL, Vance C, Troakes C, Colombrita C, Mora G, Calvo A, Verde F, Al-Sarraj S, King A, Calini D, de Belleroche J, Baas F, van der Kooi AJ, de Visser M, Ten Asbroek AL, Sapp PC, McKenna-Yasek D, Polak M, Asress S, Muñoz-Blanco JL, Strom TM, Meitinger T, Morrison KE; SLAGEN Consortium, Lauria G, Williams KL, Leigh PN, Nicholson GA, Blair IP, Leblond CS, Dion PA, Rouleau GA, Pall H, Shaw PJ, Turner MR, Talbot K, Taroni F, Boylan KB, Van Blitterswijk M, Rademakers R, Esteban-Pérez J, García-Redondo A, Van Damme P, Robberecht W, Chio A, Gellera C, Drepper C, Sendtner M, Ratti A, Glass JD, Mora JS, Basak NA, Hardiman O, Ludolph AC, Andersen PM, Weishaupt JH, Brown RH Jr, Al-Chalabi A, Silani V, Shaw CE, van den Berg LH, Veldink JH, Landers JE. NEK1 Variants Confer Susceptibility to Amyotrophic Lateral Sclerosis. Nat Genet. 2016 Sep;48(9):1037-42. doi: 10.1038/ng.3626. Epub 2016 Jul 25. PMCID: PMC5560030. PMID: 27455347

LoBue C, Denney D, Hynan LS, Rossetti HC, Lacritz LH, Hart J, Womack KB, Woon FL, Cullum CM. Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis. J Alzheimers Dis. 2016;51(3):727-36. doi: 10.3233/JAD-150895. PMCID: PMC4853649. PMID: 26890760

Staley LA, Ebbert MT, Parker S, Bailey M; Alzheimer’s Disease Neuroimaging Initiative, Ridge PG, Goate AM, Kauwe JS. Genome-wide Association Study of Prolactin Levels in Blood Plasma and Cerebrospinal Fluid. BMC Genomics. 2016 Jun 29;17 Suppl 3:436. doi: 10.1186/s12864-016-2785-0.PMCID: PMC4943503.PMID: 27357110

Staley LA, Ebbert MT, Bunker D, Bailey M; Alzheimer’s Disease Neuroimaging Initiative, Ridge PG, Goate AM, Kauwe JS. Variants in ACPP are Associated with Cerebrospinal Fluid Prostatic Acid Phosphatase Levels. BMC Genomics. 2016 Jun 29;17 Suppl 3:439. doi: 10.1186/s12864-016-2787-y. PMCID: PMC4943489. PMID: 27357282

Ebbert MT, Staley LA, Parker J, Parker S, Bailey M; Alzheimer’s Disease Neuroimaging Initiative, Ridge PG, Goate AM, Kauwe JS. Variants in CCL16 are Associated with Blood Plasma and Cerebrospinal Fluid CCL16 Protein Levels. BMC Genomics. 2016 Jun 29;17 Suppl 3:437. doi: 10.1186/s12864-016-2788-x. PMCID: PMC4943476. PMID: 27357396

Allen GI, Amoroso N, Anghel C, Balagurusamy V, Bare CJ, Beaton D, Bellotti R, Bennett DA, Boehme KL, Boutros PC, Caberlotto L, Caloian C, Campbell F, Chaibub Neto E, Chang YC, Chen B, Chen CY, Chien TY, Clark T, Das S, Davatzikos C, Deng J, Dillenberger D, Dobson RJ, Dong Q, Doshi J, Duma D, Errico R, Erus G, Everett E, Fardo DW, Friend SH, Fröhlich H, Gan J, St George-Hyslop P, Ghosh SS, Glaab E, Green RC, Guan Y, Hong MY, Huang C, Hwang J, Ibrahim J, Inglese P, Iyappan A, Jiang Q, Katsumata Y, Kauwe JS, Klein A, Kong D, Krause R, Lalonde E, Lauria M, Lee E, Lin X, Liu Z, Livingstone J, Logsdon BA, Lovestone S, Ma TW, Malhotra A, Mangravite LM, Maxwell TJ, Merrill E, Nagorski J, Namasivayam A, Narayan M, Naz M, Newhouse SJ, Norman TC, Nurtdinov RN, Oyang YJ, Pawitan Y, Peng S, Peters MA, Piccolo SR, Praveen P, Priami C, Sabelnykova VY, Senger P, Shen X, Simmons A, Sotiras A, Stolovitzky G, Tangaro S, Tateo A, Tung YA, Tustison NJ, Varol E, Vradenburg G, Weiner MW, Xiao G, Xie L, Xie Y, Xu J, Yang H, Zhan X, Zhou Y, Zhu F, Zhu H, Zhu S; Alzheimer's Disease Neuroimaging Initiative. Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. Alzheimers Dement. 2016 Jun;12(6):645-53. doi: 10.1016/j.jalz.2016.02.006. Epub 2016 Apr 11. PMCID: PMC5474755. PMID: 27079753

Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancáková A, Chen Y, Varga TV, Yaghootkar H, Luan J, Zhao JH, Willems SM, Wessel J, Wang S, Maruthur N, Michailidou K, Pirie A, van der Lee SJ, Gillson C, Al Olama AA, Amouyel P, Arriola L, Arveiler D, Aviles-Olmos I, Balkau B, Barricarte A, Barroso I, Garcia SB, Bis JC, Blankenberg S, Boehnke M, Boeing H, Boerwinkle E, Borecki IB, Bork-Jensen J, Bowden S, Caldas C, Caslake M; CVD50 consortium, Cupples LA, Cruchaga C, Czajkowski J, den Hoed M, Dunn JA, Earl HM, Ehret GB, Ferrannini E, Ferrieres J, Foltynie T, Ford I, Forouhi NG, Gianfagna F, Gonzalez C, Grioni S, Hiller L, Jansson JH, Jørgensen ME, Jukema JW, Kaaks R, Kee F, Kerrison ND, Key TJ, Kontto J, Kote-Jarai Z, Kraja AT, Kuulasmaa K, Kuusisto J, Linneberg A, Liu C, Marenne G, Mohlke KL, Morris AP, Muir K, Müller-Nurasyid M, Munroe PB, Navarro C, Nielsen SF, Nilsson PM, Nordestgaard BG, Packard CJ, Palli D, Panico S, Peloso GM, Perola M, Peters A, Poole CJ, Quirós JR, Rolandsson O, Sacerdote C, Salomaa V, Sánchez MJ, Sattar N, Sharp SJ, Sims R, Slimani N, Smith JA, Thompson DJ, Trompet S, Tumino R, van der A DL, van der Schouw YT, Virtamo J, Walker M, Walter K; GERAD_EC Consortium; Neurology Working Group of the Cohorts for Heart; Aging Research in Genomic Epidemiology (CHARGE); Alzheimer’s Disease Genetics Consortium; Pancreatic Cancer Cohort Consortium; European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD); EPIC-InterAct, Abraham JE, Amundadottir LT, Aponte JL, Butterworth AS, Dupuis J, Easton DF, Eeles RA, Erdmann J, Franks PW, Frayling TM, Hansen T, Howson JM, Jørgensen T, Kooner J, Laakso M, Langenberg C, McCarthy MI, Pankow JS, Pedersen O, Riboli E, Rotter JI, Saleheen D, Samani NJ, Schunkert H, Vollenweider P, O'Rahilly S; CHARGE consortium; CHD Exome+ Consortium; CARDIOGRAM Exome Consortium, Deloukas P, Danesh J, Goodarzi MO, Kathiresan S, Meigs JB, Ehm MG, Wareham NJ, Waterworth DM. A Genomic Approach to Therapeutic Target Validation Identifies a Glucose-lowering GLP1R Variant Protective for Coronary Heart Disease. Sci Transl Med. 2016 Jun 1;8(341):341ra76. doi: 10.1126/scitranslmed.aad3744. PMCID: PMC5219001. PMID: 27252175

Karch CM, Ezerskiy LA, Bertelsen S; Alzheimer’s Disease Genetics Consortium (ADGC), Goate AM. Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One. 2016 Feb 26;11(2):e0148717. doi: 10.1371/journal.pone.0148717. eCollection 2016.PMCID: PMC4769299. PMID: 26919393

2015

Leung YY, Kuksa PP, Amlie-Wolf A, Valladares O, Ungar LH, Kannan S, Gregory BD, Wang LS. DASHR: Database of Small Human Noncoding RNAs. Nucleic Acids Res. 2016 Jan 4;44(D1):D216-22. doi: 10.1093/nar/gkv1188. Epub 2015 Nov 8. PMCID: PMC4702848. PMID: 26553799

Deming Y, Xia J, Cai Y, Lord J, Holmans P, Bertelsen S, Holtzman D, Morris JC, Bales K, Pickering EH, Kauwe J, Goate A, Cruchaga C; Alzheimer's Disease Neuroimaging Initiative (ADNI). A Potential Endophenotype for Alzheimer’s Disease: Cerebrospinal Fluid Clusterin. Neurobiol Aging. 2016 Jan;37:208.e1-208.e9. doi: 10.1016/j.neurobiolaging.2015.09.009. Epub 2015 Sep 25. PMCID: PMC5118651. PMID: 2654563

Nho K, Kim S, Risacher SL, Shen L, Corneveaux JJ, Swaminathan S, Lin H, Ramanan VK, Liu Y, Foroud TM, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR Jr, Weiner MW, Baldwin CT, Lunetta KL, Farrer LA; MIRAGE (Multi-Institutional Research on Alzheimer Genetic Epidemiology) Study, Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H; AddNeuroMed Consortium, McDonald BC, Farlow MR, Ghetti B; Indiana Memory and Aging Study, Huentelman MJ, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative. Protective Variant for Hippocampal Atrophy Identified by Whole Exome Sequencing. Ann Neurol. 2015 Mar;77(3):547-52. doi: 10.1002/ana.24349. Epub 2015 Feb 14.PMCID: PMC4387567. PMID: 25559091

2014

Gross AL, Sherva R, Mukherjee S, Newhouse S, Kauwe JS, Munsie LM, Waterston LB, Bennett DA, Jones RN, Green RC, Crane PK; Alzheimer's Disease Neuroimaging Initiative; GENAROAD Consortium; AD Genetics Consortium. Calibrating Longitudinal Cognition in Alzheimer's Disease Across Diverse Test Batteries and Datasets. Neuroepidemiology. 2014;43(3-4):194-205. doi: 10.1159/000367970. Epub 2014 Nov 13. PMCID: PMC4297570. PMID: 25402421

Bailey JN, Pericak-Vance MA, Haines JL. The Impact of the Human Genome Project on Complex Disease. Genes (Basel). 2014 Jul 16;5(3):518-35. doi: 10.3390/genes5030518. PMCID: PMC4198915. PMID: 25032678

Bennett DA, Yu L, De Jager PL. Building a Pipeline to Discover and Validate Novel Therapeutic Targets and Lead Compounds for Alzheimer's Disease. Biochem Pharmacol. 2014 Apr 15;88(4):617-30. doi: 10.1016/j.bcp.2014.01.037. Epub 2014 Feb 6. PMCID: PMC4054869. PMID: 24508835

2013

Ryvkin P, Leung YY, Silverman IM, Childress M, Valladares O, Dragomir I, Gregory BD, Wang LS. HAMR: High-throughput Annotation of Modified Ribonucleotides. RNA. 2013 Dec;19(12):1684-92. doi: 10.1261/rna.036806.112. Epub 2013 Oct 22. PMCID: PMC3884653. PMID: 24149843

2012

Leung YY, Chang CQ, Hung YS. An Integrated Approach for Identifying Wrongly Labelled Samples When Performing Classification in Microarray Data. PLoS One. 2012;7(10):e46700. doi: 10.1371/journal.pone.0046700. Epub 2012 Oct 17.PMCID: PMC3474777. PMID: 23082127

Cruchaga C, Kauwe JS, Nowotny P, Bales K, Pickering EH, Mayo K, Bertelsen S, Hinrichs A; Alzheimer's Disease Neuroimaging Initiative, Fagan AM, Holtzman DM, Morris JC, Goate AM. Cerebrospinal Fluid APOE Levels: an Edophenotype for Genetic Studies for Alzheimer's Disease. Hum Mol Genet. 2012 Oct 15;21(20):4558-71. Epub 2012 Jul 20. PMCID: PMC3459471. PMID: 22821396