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Title | DNA from multiple viral species is associated with Alzheimer's disease risk. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Tejeda M, Farrell J, Zhu C, Wetzler L, Lunetta KL, Bush WS, Martin ER, San Wang L-, Schellenberg GD, Pericak-Vance MA, Haines JL, Farrer LA, Sherva R |
Journal | Alzheimers Dement |
Date Published | 08/2023 |
ISSN | 1552-5279 |
Abstract | INTRODUCTION: Multiple infectious agents, including viruses, bacteria, fungi, and protozoa, have been linked to Alzheimer's disease (AD) risk by independent lines of evidence. We explored this association by comparing the frequencies of viral species identified in a large sample of AD cases and controls. METHODS: DNA sequence reads that did not align to the human genome in sequences were mapped to viral reference sequences, quantified, and then were tested for association with AD in whole exome sequences (WES) and whole genome sequences (WGS) datasets. RESULTS: Several viruses were significant predictors of AD according to the machine learning classifiers. Subsequent regression analyses showed that herpes simplex type 1 (HSV-1) (odds ratio [OR] = 3.71, p = 8.03 × 10-4) and human papillomavirus 71 (HPV-71; OR = 3.56, p = 0.02), were significantly associated with AD after Bonferroni correction. The phylogenetic-related cluster of Herpesviridae was significantly associated with AD in several strata of the data (p < 0.01). DISCUSSION: Our results support the hypothesis that viral infection, especially HSV-1, is associated with AD risk. |
DOI | 10.1002/alz.13414 |
Alternate Journal | Alzheimers Dement |
PubMed ID | 37578203 |
Grant List | U01 AG032984 / AG / NIA NIH HHS / United States R01 AG033193 / AG / NIA NIH HHS / United States U01AG049506 / HL / NHLBI NIH HHS / United States U01AG049507 / HL / NHLBI NIH HHS / United States / AG / NIA NIH HHS / United States RF1 AG057519 / NH / NIH HHS / United States R01 AG048927 / NH / NIH HHS / United States U19 AG068753 / NH / NIH HHS / United States U01 AG062602 / NH / NIH HHS / United States R01-AG076002 / NH / NIH HHS / United States |