Interplay between Socioeconomic Markers and Polygenic Predisposition on Timing of Dementia Diagnosis.

TitleInterplay between Socioeconomic Markers and Polygenic Predisposition on Timing of Dementia Diagnosis.
Publication TypeJournal Article
Year of Publication2020
AuthorsAjnakina O, Cadar D, Steptoe A
JournalJ Am Geriatr Soc
Volume68
Issue7
Pagination1529-1536
Date Published07/2020
ISSN1532-5415
Abstract

OBJECTIVES: Identifying the interplay between socioeconomic markers (education and financial resources) and polygenetic predisposition influencing the time of dementia and the diagnosis of clinical Alzheimer's disease (AD) dementia is of central relevance for preventive strategies.

DESIGN: Prospective cohort design.

SETTING: The English Longitudinal Study of Aging is a household survey data set of a representative sample.

PARTICIPANTS: A total of 7,039 individuals aged 50 years and older participated in the study. Of these, 320 (4.6%) were diagnosed with dementia over the 10-year follow-up.

MEASUREMENTS: Polygenic score (PGS) for Alzheimer's disease (AD-PGS) was calculated using summary statistics from the International Genomics of Alzheimer's Project. An accelerated failure time survival model was used to investigate interactions between AD-PGS and socioeconomic markers on the timing of dementia and clinical AD dementia diagnosis.

RESULTS: A one standard deviation increase in AD-PGS was associated with an accelerated time to dementia diagnosis by 4.8 months. The presence of the apolipoprotein E gene (APOE-ε4) was associated with an earlier dementia onset by approximately 24.9 months, whereas intermediate and low levels of wealth were associated with an accelerated time to dementia diagnosis by 12.0 months and 18.7 months, respectively. A multiplicative interaction between AD-PGS and years of completed schooling in decelerating the time to clinical AD dementia by 3.0 months suggests educational attainment may serve as a protective mechanism against AD diagnosis among older people with a higher polygenic risk. Interaction between AD-PGS and lower wealth accelerated the time to clinical AD dementia diagnosis by 21.1 to 24.1 months.

CONCLUSION: Socioeconomic markers influence the time to dementia and clinical AD dementia diagnosis, particularly in those with a higher polygenic predisposition. J Am Geriatr Soc 68:1529-1536, 2020.

DOI10.1111/jgs.16406
Alternate JournalJ Am Geriatr Soc
PubMed ID32187654
PubMed Central IDPMC7363562
Grant List / MRC_ / Medical Research Council / United Kingdom
U01 AG016976 / AG / NIA NIH HHS / United States
503176 / / Alzheimer's Research UK /
R01 HL105756 / HL / NHLBI NIH HHS / United States
01GI0102 / / German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) /
R01 AG033193 / AG / NIA NIH HHS / United States
01GI0420 / / German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) /
R01 AG017644 / AG / NIA NIH HHS / United States
01GI0711 / / German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) /
N01-AG-12100 / / AGES /
RO1AG7644 / AG / NIA NIH HHS / United States
U24 AG021886 / AG / NIA NIH HHS / United States
U01 AG032984 / AG / NIA NIH HHS / United States
PDF-2018-11-ST2-020 / / NIHR postdoctoral fellowship /
082604/2/07/Z / WT_ / Wellcome Trust / United Kingdom
ADGC-10-196728 / / Alzheimer's Association / United States
AG081220 / AG / NIA NIH HHS / United States
/ WT_ / Wellcome Trust / United Kingdom