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Title | Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Godrich D, Martin ER, Schellenberg G, Pericak-Vance MA, Cuccaro M, Scott WK, Kukull W, Montine T, Beecham GW |
Journal | Alzheimers Dement |
Volume | 18 |
Issue | 12 |
Pagination | 2403-2412 |
Date Published | 12/2022 |
ISSN | 1552-5279 |
Keywords | Alzheimer Disease, Brain, Cognitive Dysfunction, Humans, Lewy Bodies, Neurofibrillary Tangles, Plaque, Amyloid |
Abstract | INTRODUCTION: Alzheimer disease (AD) and related dementias are characterized by damage caused by neuropathological lesions in the brain. These include AD lesions (plaques and tangles) and non-AD lesions such as vascular injury or Lewy bodies. We report here an assessment of lesion association to dementia in a large clinic-based population. METHODS: We identified 5272 individuals with neuropathological data from the National Alzheimer's Coordinating Center. Individual lesions, as well as a neuropathological composite score (NPCS) were tested for association with dementia, and both functional and neurocognitive impairment using regression models. RESULTS: Most individuals exhibited mixed pathologies, especially AD lesions in combination with non-AD lesions. All lesion types were associated with one or more clinical outcomes; most even while controlling for AD pathology. The NPCS was also associated with clinical outcomes. DISCUSSION: These data suggest mixed-type pathologies are extremely common in a clinic-based population and may contribute to dementia and cognitive impairment. |
DOI | 10.1002/alz.12516 |
Alternate Journal | Alzheimers Dement |
PubMed ID | 35142102 |
PubMed Central ID | PMC9360193 |
Grant List | P30 AG010133 / AG / NIA NIH HHS / United States U24 AG072122 / AG / NIA NIH HHS / United States U01 AG032984 / AG / NIA NIH HHS / United States P30 AG062421 / AG / NIA NIH HHS / United States P30 AG062422 / AG / NIA NIH HHS / United States P30 AG062429-01 / AG / NIA NIH HHS / United States P30 AG062422-01 / AG / NIA NIH HHS / United States P30 AG062428-01 / AG / NIA NIH HHS / United States P30 AG072976 / AG / NIA NIH HHS / United States R01 AG062695 / AG / NIA NIH HHS / United States P30 AG062421-01 / AG / NIA NIH HHS / United States P30 AG013854 / AG / NIA NIH HHS / United States P30 AG053760 / AG / NIA NIH HHS / United States P30 AG072975 / AG / NIA NIH HHS / United States U01 AG016976 / AG / NIA NIH HHS / United States P30 AG062715-01 / AG / NIA NIH HHS / United States |