ADGC Publications

Found 22 results
Filters: Author is Haines, Jonathan L and Keyword is Polymorphism, Single Nucleotide  [Clear All Filters]
2024
Ray NR, Kunkle BW, Hamilton-Nelson K, Kurup JT, Rajabli F, Qiao M, Vardarajan BN, Cosacak MI, Kizil C, Jean-Francois M et al..  2024.  Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.. Alzheimers Dement. 20(8):5247-5261.
2022
Shade LMp, Katsumata Y, Hohman TJ, Nho K, Saykin AJ, Mukherjee S, Boehme KL, Kauwe JSk, Farrer LA, Schellenberg GD et al..  2022.  Genome-wide association study of brain arteriolosclerosis.. J Cereb Blood Flow Metab. 42(8):1437-1450.
2019
Patel D, Mez J, Vardarajan BN, Staley L, Chung J, Zhang X, Farrell JJ, Rynkiewicz MJ, Cannon-Albright LA, Teerlink CC et al..  2019.  Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry.. JAMA Netw Open. 2(3):e191350.
2017
Huang K-L, Marcora E, Pimenova AA, Di Narzo AF, Kapoor M, Jin SChih, Harari O, Bertelsen S, Fairfax BP, Czajkowski J et al..  2017.  A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.. Nat Neurosci. 20(8):1052-1061.
Desikan RS, Fan CChieh, Wang Y, Schork AJ, Cabral HJ, L Cupples A, Thompson WK, Besser L, Kukull WA, Holland D et al..  2017.  Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.. PLoS Med. 14(3):e1002258.
Mez J, Chung J, Jun G, Kriegel J, Bourlas AP, Sherva R, Logue MW, Barnes LL, Bennett DA, Buxbaum JD et al..  2017.  Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.. Alzheimers Dement. 13(2):119-129.
2016
Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD et al..  2016.  Assessment of the genetic variance of late-onset Alzheimer's disease.. Neurobiol Aging. 41:200.e13-200.e20.
Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD et al..  2016.  Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.. Neurobiol Aging. 38:141-150.
Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML et al..  2016.  Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.. Alzheimers Dement. 12(3):233-43.
2015
Ghani M, Reitz C, Cheng R, Vardarajan BNarayan, Jun G, Sato C, Naj A, Rajbhandary R, Wang L-S, Valladares O et al..  2015.  Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.. JAMA Neurol. 72(11):1313-23.
Barral S, Cheng R, Reitz C, Vardarajan B, Lee J, Kunkle B, Beecham G, Cantwell LS, Pericak-Vance MA, Farrer LA et al..  2015.  Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease.. Alzheimers Dement. 11(12):1397-1406.
Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen C-H et al..  2015.  Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.. Circulation. 131(23):2061-2069.
2014
Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YSon, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang L-S et al..  2014.  Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.. JAMA Neurol. 71(11):1394-404.
Jun G, Asai H, Zeldich E, Drapeau E, Chen CD, Chung J, Park J-H, Kim S, Haroutunian V, Foroud T et al..  2014.  PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.. Ann Neurol. 76(3):379-92.
2013
McDavid A, Crane PK, Newton KM, Crosslin DR, McCormick W, Weston N, Ehrlich K, Hart E, Harrison R, Kukull WA et al..  2013.  Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records.. PLoS One. 8(6):e63481.
Cruchaga C, Kauwe JSK, Harari O, Jin SChih, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D et al..  2013.  GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.. Neuron. 78(2):256-68.
Holton P, Ryten M, Nalls M, Trabzuni D, Weale ME, Hernandez D, Crehan H, J Gibbs R, Mayeux R, Haines JL et al..  2013.  Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.. Ann Hum Genet. 77(2):85-105.
Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BNarayan, Wang L-S, Valladares O, Lin C-F, Larson EB, Graff-Radford NR et al..  2013.  Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.. JAMA. 309(14):1483-92.
2012
Zou F, Chai HSeng, Younkin CS, Allen M, Crook J, V Pankratz S, Carrasquillo MM, Rowley CN, Nair AA, Middha S et al..  2012.  Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.. PLoS Genet. 8(6):e1002707.
Jun G, Vardarajan BN, Buros J, Yu C-E, Hawk MV, Dombroski BA, Crane PK, Larson EB, Mayeux R, Haines JL et al..  2012.  Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.. Arch Neurol. 69(10):1270-9.
Allen M, Zou F, Chai HSeng, Younkin CS, Crook J, V Pankratz S, Carrasquillo MM, Rowley CN, Nair AA, Middha S et al..  2012.  Novel late-onset Alzheimer disease loci variants associate with brain gene expression.. Neurology. 79(3):221-8.
2011
Naj AC, Jun G, Beecham GW, Wang L-S, Vardarajan BNarayan, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK et al..  2011.  Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.. Nat Genet. 43(5):436-41.