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2024
Guo X, Yang Y-Y, Zhou R, Tian G, Shan C, Liu J-M, Li R. Causal effect of blood osteocalcin on the risk of Alzheimer's disease and the mediating role of energy metabolism. Transl Psychiatry. 2024 May 20;14(1):205. doi: 10.1038/s41398-024-02924-w. PMID: 38769320 PMCID: PMC11106250.
2023
Ding P, Gorenflo MP, Zhu X, Xu R. Aspirin Use and Risk of Alzheimer's Disease: A 2-Sample Mendelian Randomization Study. J Alzheimers Dis. 2023;92(3):989-1000. doi: 10.3233/JAD-220787. PMID: 36846997. PMCID: PMC11220559.
Zhang Q, Li Q, Zhao H, Shu M, Luo M, Li Y, Ding Y, Shi S, Cheng X, Niu Q. Neurodegenerative disease and antioxidant biomarkers: A bidirectional Mendelian randomization study.Front Neurol. 2023 Mar 23:14:1158366. doi: 10.3389/fneur.2023.1158366. eCollection 2023. PMID: 37034095 PMCID: PMC10076659.
Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM. The complex genetic architecture of Alzheimer's disease: novel insights and future directions. EBioMedicine. 2023 Apr:90:104511. doi: 10.1016/j.ebiom.2023.104511. Epub 2023 Mar 10. PMID: 36907103. PMCID: PMC10024184.
Yao Y, Charkraborty D, Zhang L, Shen X; Alzheimer's Disease Neuroimaging Initiative; Pan W. Deep causal feature extraction and inference with neuroimaging genetic data. Stat Med. 2023 Sep 10;42(20):3665-3684. doi: 10.1002/sim.9824. Epub 2023 Jun 19. PMID: 37336556. PMCID: PMC11193942.
Gao F, Pan R, Fan T, Liu L, Pan H. Identification of heel bone mineral density as a risk factor of Alzheimer's disease by analyzing large-scale genome-wide association studies datasets. Front Cell Dev Biol. 2023 Nov 30:11:1247067. doi: 10.3389/fcell.2023.1247067. eCollection 2023. PMID: 38099291. PMCID: PMC10720361.
Pan M, Roe JM, Nudel R, Schork AJ, Iakunchykova O, Fjell AM, Walhovd KB, Werge T, Chen CH, Benros ME, Wang Y. Circulating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study. Translational Psychiatry. 2023 May 24;13(1), 174
Wu BS, Zhang YR, Yang L, Zhang W, Deng YT, Chen CD, Feng JF, Cheng W, Yu JT. Polygenic Liability to Alzheimer’s Disease Is Associated with a Wide Range of Chronic Diseases: A Cohort Study of 312,305 Participants. J Alzheimers Dis. 2023 Jan 3;91(1):437-447. PMID: 36442194.
2022
Yeung CHC, Au Yeung SL, & Schooling CM. Association of autoimmune diseases with Alzheimer’s disease: A mendelian randomization study. J Psychiatr Res. 2022 Nov 5;155:550-558. doi: 10.1016/j.jpsychires.2022.09.052. PMID: 36198219.
Ma J, Qiu S. Genetic variant rs11136000 upregulates clusterin expression and reduces Alzheimer's disease risk Front Neurosci. 2022 Aug 10;16:926830. doi: 10.3389/fnins.2022.926830. eCollection 2022. PMID: 36033622
Hu Y, Zhang Y, Zhang H, Gao S, Wang L, Wang T, Han Z, Sun BL, Liu G. Cognitive performance protects against Alzheimer’s disease independently of educational attainment and intelligence. Mol Psychiatry. 2022 Jul 15;27(10):4297-4306. PMID: 35840796.
Hu Y, Zhang Y, Zhang H, Gao S, Wang L, Wang T, Han Z; International Genomics of Alzheimer's Project (IGAP), Liu G. Mendelian randomization highlights causal association between genetically increased C-reactive protein levels and reduced Alzheimer's disease risk. Alzheimers Dement. 2022 Oct;18(10):2003-2006. doi: 10.1002/alz.12687. Epub 2022 May 22. PMID: 35598332
Ning J, Huang SY, Chen SD, Zhang YR, Huang YY, Yu JT. Investigating Casual Associations Among Gut Microbiota, Metabolites, and Neurodegenerative Diseases: A Mendelian Randomization Study. J Alzheimers Dis. 2022;87(1):211-222. doi: 10.3233/JAD-215411. PMID: 35275534
Kjeldsen EW, Thomassen JQ, Juul Rasmussen I, Nordestgaard BG, Tybjærg-Hansen A, Frikke-Schmidt R. Plasma high-density lipoprotein cholesterol and risk of dementia: observational and genetic studies. Cardiovasc Res. 2022 Mar 25;118(5):1330-1343. doi: 10.1093/cvr/cvab164. PMID: 33964140
2021
Creese B, Arathimos R, Brooker H, Aarsland D, Corbett A, Lewis C, Ballard C, Ismail Z. Genetic risk for Alzheimer's disease, cognition, and mild behavioral impairment in healthy older adults. Alzheimers Dement (Amst). 2021 Mar 17;13(1):e12164. doi: 10.1002/dad2.12164. eCollection 2021.PMID: 33748395
Liu H, Zhang Y, Hu Y, Zhang H, Wang T, Han Z, Gao S, Wang L, Liu G. Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer's disease Genes Nutr. 2021 Oct 29;16(1):19. doi: 10.1186/s12263-021-00700-9. PMID: 34715780
Carpanini SM, Harwood JC, Baker E, Torvell M, The Gerad Consortium, Sims R, Williams J, Morgan BP. The Impact of Complement Genes on the Risk of Late-Onset Alzheimer's Disease. Genes (Basel). 2021 Mar 20;12(3):443. doi: 10.3390/genes12030443. PMID: 33804666
Knutson KA, Pan W. Integrating brain imaging endophenotypes with GWAS for Alzheimer's disease. Quant Biol. 2021 Jun;9(2):185-200. doi: 10.1007/s40484-020-0202-9.PMID: 35399757
Fani L, Georgakis MK, Ikram MA, Ikram MK, Malik R, Dichgans M. Circulating biomarkers of immunity and inflammation, risk of Alzheimer's disease, and hippocampal volume: a Mendelian randomization study. Transl Psychiatry. 2021 May 17;11(1):291. doi: 10.1038/s41398-021-01400-z. PMID: 34001857
2020
Yeung CHC, Lau KWD, Au Yeung SL, Schooling CM. Amyloid, tau and risk of Alzheimer's disease: a Mendelian randomization study. Eur J Epidemiol. 2021 Jan;36(1):81-88. doi: 10.1007/s10654-020-00683-8. Epub 2020 Sep 14. PMID: 32929646.
Sahaf Naeini A, Farooq A, Bjørås M, Wanga, J. IGAP-integrative Genome Analysis Pipeline Reveals New Gene Regulatory Model Associated with Nonspecific TF-DNA Binding Affinity. Comput Struct Biotechnol J. 2020; 18: 1270–1286. doi: 10.1016/j.csbj.2020.05.024. PMCID: PMC7303559. PMID: 32612751
Xiao X, Jiao B, Liao X, Zhang W, Yuan Z, Guo L, Wang X, Zhou L, Liu X, Yan, X, Tang B, Shen L. Association of Genes Involved in the Metabolic Pathways of Amyloid-β and Tau Proteins With Sporadic Late-Onset Alzheimer's Disease in the Southern Han Chinese Population. Front Aging Neurosci. 2020; 12: 584801. doi: 10.3389/fnagi.2020.584801. PMCID: PMC7677357. PMID: 33240075
Anderson EL, Howe LD, Wade KH, Ben-Shlomo Y, Hill D, Deary IJ, Sanderson EC, Zheng J, Korologou-Linden R, Stergiakouli E, Smith GD, Davies NM, Hemani G. Education, Intelligence and Alzheimer's Disease: Evidence from a Multivariable Two-sample Mendelian Randomization Study. Int J Epidemiol. 2020 Aug; 49(4): 1163–1172. doi: 10.1093/ije/dyz280. PMCID: PMC7660137. PMID: 32003800
Lutz MW, Sprague D, Barrera J, Chiba-Falek O. Shared Genetic Etiology Underlying Alzheimer's Disease and Major Depressive Disorder. Transl Psychiatry. 2020; 10: 88. doi: 10.1038/s41398-020-0769- PMCID: PMC7062839. PMID: 32152295
2019
Juul Rasmussen I, Tybjærg-Hansen A, Rasmussen K, Nordestgaard B, Frikke-Schmidtcorresponding R. Blood–brain Barrier Transcytosis Genes, Risk of Dementia and Stroke: a Prospective Cohort Study of 74,754 Individuals. Eur J Epidemiol. 2019; 34(6): 579–590. doi: 10.1007/s10654-019-00498-2. PMCID: PMC6497814. PMID: 30830563
Wang L, Qiao Y, Zhang H, Zhang Y, Hua J, Jin S, Liu G. Circulating Vitamin D Levels and Alzheimer's Disease: A Mendelian Randomization Study in the IGAP and UK Biobank. J Alzheimers Dis. 2019 Dec 2. doi: 10.3233/JAD-190713. PMID:31815694
Zhou Y, Sun X, Zhou M. Body Shape and Alzheimer's Disease: A Mendelian Randomization Analysis. Front Neurosci. 2019 Oct 10;13:1084. doi: 10.3389/fnins.2019.01084. eCollection 2019. PMID: 31649504
Chaudhury S, Brookes KJ, Patel T, Fallows A, Guetta-Baranes T, Turton JC, Guerreiro R, Bras J, Hardy J, Francis PT, Croucher R, Holmes C, Morgan K, Thomas AJ. Alzheimer's Disease Polygenic Risk Score as a Predictor of Conversion from Mild-cognitive Impairment. Transl Psychiatry. 2019 May 24;9(1):154. doi: 10.1038/s41398-019-0485-7. Erratum in: Transl Psychiatry. 2019 Jun 11;9(1):167. PMID: 31127079
Leonenko G, Sims R, Shoai M, Frizzati A, Bossù P, Spalletta G, Fox NC, Williams J; GERAD consortium, Hardy J, Escott-Price V. Polygenic Risk and Hazard Scores for Alzheimer's Disease Prediction. Ann Clin Transl Neurol. 2019 Feb 18;6(3):456-465. doi: 10.1002/acn3.716. eCollection 2019 Mar. PMID: 30911569
Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S; Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Genetic and Lifestyle Risk Factors for MRI-defined Brain Infarcts in a Population-based Setting. Neurology. 2019 Jan 16. pii: 10.1212/WNL.0000000000006851. doi: 10.1212/WNL.0000000000006851. [Epub ahead of print]. PMCID: PMC6369905. PMID: 30651383
2018
Hao S, Wang R, Zhang Y, Zhan H. Prediction of Alzheimer's Disease-Associated Genes by Integration of GWAS Summary Data and Expression Data. Front Genet. 2018; 9: 653. doi: 10.3389/fgene.2018.00653. PMCID: PMC6330278. PMID: 30666269
Girdhar K, Hoffman GE, Jiang Y, Brown L, Kundakovic M, Hauberg ME, Francoeur NJ, Wang Y-C, Shah H, Kavanagh DH, Zharovsky E, Jacobov R, Wiseman JR, Park R, Johnson JS, Kassim BS, Sloofman L, Mattei E, Weng Z, Sieberts SK, Peters MA, Harris BT, Lipska BK, Sklar P, Roussos P, Akbarian S. Cell-specific Histone Modification Maps in the Human Frontal Lobe Link Schizophrenia Risk to the Neuronal Epigenome. Nat Neurosci. 2018 Aug;21(8):1126-1136. PMCID: PMC6063773. PMID: 30038276
Ni H, Xu M, Zhan GL, Fan Y, Zhou H, Jiang HY, Lu WH, Tan L, Zhang DF, Yao YG, Zhang C. The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer's Disease. J Alzheimers Dis. 2018 Jul 12. DOI: 10.3233/JAD-180276. PMID: 30010129
Kunutsor SK, Laukkanen JA, Burgess S. Genetically Elevated Gamma-glutamyltransferase and Alzheimer's Disease. Exp Gerontol. 2018 Jun;106:61-66. PMCID: PMC5915296. PMID: 29505811
Grace C, Clarke R, Goel A, Farrall M, Watkins H, Hopewell JC. Lack of Genetic Support for Shared Aetiology of Coronary Artery Disease and Late-onset Alzheimer's Disease. Sci Rep. 2018 May 8;8(1):7102. PMCID: PMC5940751. PMID: 29740026
Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller BL, Andreassen OA, Dale AM, Barkovich AJ, Yokoyama JS, Desikan RS; International FTD-Genomics Consortium (IFGC); International Parkinson’s Disease Genetics Consortium (IPDGC); International Genomics of Alzheimer’s Project (IGAP). CXCR4 Involvement in Neurodegenerative Diseases. Transl Psychiatry. 2018 Apr 11;8(1):73. doi: 10.1038/s41398-017-0049-7. PMCID: PMC5893558. PMID: 29636460
Nordestgaard LT, Tybjærg-Hansen A, Rasmussen KL, Nordestgaard BG, Frikke-Schmidt R. Genetic Variation in Clusterin and Risk of Dementia and Ischemic Vascular Disease in the General Population: Cohort Studies and Meta-analyses of 362,338 individuals. BMC Med. 2018 Mar 14;16(1):39. PMCID: PMC5851250. PMID: 29534716
Chaudhury S, Patel T, Barber IS, Guetta-Baranes T, Brookes KJ, Chappell S, Turton J, Guerreiro R, Bras J, Hernandez D, Singleton A, Hardy J, Mann D; ARUK Consortium, Morgan K. Polygenic Risk Score in Postmortem Diagnosed Sporadic Early-onset Alzheimer's Disease. Neurobiol Aging. 2018 Feb;62:244. PMCID: PMC5995122. PMID: 29103623
Williams DM, Karlsson IK, Pedersen NL, Hägg S. Circulating Insulin-like Growth Factors and Alzheimer Disease: A Mendelian Randomization Study. Neurology. 2018 Jan 23;90(4):e291-e297. PMCID: PMC5798653. PMID: 29282328
Del-Aguila JL, Fernández MV, Schindler S, Ibanez L, Deming Y, Ma S, Saef B, Black K, Budde J, Norton J, Chasse R; Alzheimer’s Disease Neuroimaging Initiative (ADNI), Harari O, Goate A, Xiong C, Morris JC, Cruchaga C. Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline. J Alzheimers Dis. 2018;62(2):745-756. PMCID: PMC5989565. PMID: 29480181
2017
Larsson SC, Traylor M, Malik R, Dichgans M, Burgess S, Markus HS; CoSTREAM Consortium, on behalf of the International Genomics of Alzheimer’s Project. Modifiable pathways in Alzheimer's disease: Mendelian Randomization Analysis.BMJ. 2017 Dec 6;359:j5375. PMCID: PMC5717765. PMID: 29212772
Patel T, Brookes KJ, Turton J, Chaudhury S, Guetta-Baranes T, Guerreiro R, Bras J, Hernandez D, Singleton A, Francis PT, Hardy J, Morgan K. Whole-exome Sequencing of the BDR Cohort: Evidence to Support the Role of the PILRA Gene in Alzheimer's Disease. Neuropathol Appl Neurobiol. 2017 Nov 27. PMCID: PMC6005734. PMID: 29181857
McKenzie AT, Moyon S, Wang M, Katsyv I, Song WM, Zhou X, Dammer EB, Duong DM, Aaker J, Zhao Y, Beckmann N, Wang P, Zhu J, Lah JJ, Seyfried NT, Levey AI, Katsel P, Haroutunian V, Schadt EE, Popko B, Casaccia P, Zhang B. Multiscale Network Modeling of Oligodendrocytes Reveals Molecular Components of Myelin Dysregulation in Alzheimer's Disease. Mol Neurodegener. 2017 Nov 6;12(1):82. PMCID: PMC5674813. PMID: 29110684
Feng YA, Cho K, Lindstrom S, Kraft P, Cormack J; IGAP Consortium, Colorectal Transdisciplinary Study (CORRECT); Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE); Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE); Transdisciplinary Research in Cancer of the Lung (TRICL), Liang L, Driver JA. Investigating the Genetic Relationship Between Alzheimer's Disease and Cancer Using GWAS Summary Statistics. Hum Genet. 2017 Oct;136(10):1341-1351. PMCID: PMC5693762. PMID: 28780673
Larsson SC, Markus HS. Branched-chain Amino Acids and Alzheimer's Disease: a Mendelian Randomization Analysis. Sci Rep. 2017 Oct 19;7(1):13604. PMCID: PMC5648806. PMID: 29051501
Wang XF, Lin X, Li DY, Zhou R, Greenbaum J, Chen YC, Zeng CP, Peng LP, Wu KH, Ao ZX, Lu JM, Guo YF, Shen J, Deng HW. Linking Alzheimer's Disease and Type 2 diabetes: Novel Shared Susceptibility Genes Detected by cFDR Approach. J Neurol Sci. 2017 Sep 15;380:262-272. PMCID: PMC6693589. PMID: 28870582
Qvist P, Christensen JH, Vardya I, Rajkumar AP, Mørk A, Paternoster V, Füchtbauer EM, Pallesen J, Fryland T, Dyrvig M, Hauberg ME, Lundsberg B, Fejgin K, Nyegaard M, Jensen K, Nyengaard JR, Mors O, Didriksen M, Børglum AD. The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice. Biol Psychiatry. 2017 Jul 1;82(1):62-76. DOI: 10.1016/j.biopsych.2016.08.037. PMID: 27837920
Nordestgaard LT, Tybjærg-Hansen A, Nordestgaard BG, Frikke-Schmidt R. Body Mass Index and Risk of Alzheimer's Disease: A Mendelian Randomization Study of 399,536 Individuals. J Clin Endocrinol Metab. 2017 Jul 1;102(7):2310-2320. PMCID: PMC5505195. PMID: 28609829
Carrasquillo MM, Allen M, Burgess JD, Wang X, Strickland SL, Aryal S, Siuda J, Kachadoorian ML, Medway C, Younkin CS, Nair A, Wang C, Chanana P, Serie D, Nguyen T, Lincoln S, Malphrus KG, Morgan K, Golde TE, Price ND, White CC, De Jager PL, Bennett DA, Asmann YW, Crook JE, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. A Candidate Regulatory Variant at the TREM Gene Cluster Associates with Decreased Alzheimer's Disease Risk and Increased TREML1 and TREM2 Brain Gene Expression. Alzheimer's Dement. 2017 Jun;13(6):663-673. PMCID: PMC5462884. PMID: 27939925
Benn M, Nordestgaard BG, Frikke-Schmidt R, Tybjærg-Hansen A. Low LDL Cholesterol, PCSK9 and HMGCR Genetic Variation, and Risk of Alzheimer's Disease and Parkinson's Disease: Mendelian Randomization Study. BMJ. 2017 Apr 24;357:j1648. Erratum in: BMJ. 2017 Jun 29;357:j3170. PMCID: PMC5421439. PMID: 28438747
Gibson J, Russ TC, Adams MJ, Clarke TK, Howard DM, Hall LS, Fernandez-Pujals AM, Wigmore EM, Hayward C, Davies G, Murray AD, Smith BH, Porteous DJ, Deary IJ, McIntosh AM. Assessing the Presence of Shared Genetic Architecture Between Alzheimer's Disease and Major Depressive Disorder Using Genome-wide Association Data. Transl Psychiatry. 2017 Apr 18;7(4). PMCID: PMC5416691. PMID: 28418403
Karlsson IK, Ploner A, Song C, Gatz M, Pedersen NL, Hägg S. Genetic Susceptibility to Cardiovascular Disease and Risk of Dementia. Transl Psychiatry. 2017 May 30;7(5):e1142. PMCID: PMC5534941. PMID: 28556832
McLaughlin RL, Schijven D, van Rheenen W, van Eijk KR, O'Brien M, Kahn RS, Ophoff RA, Goris A, Bradley DG, Al-Chalabi A, van den Berg LH, Luykx JJ, Hardiman O, Veldink JH; Project MinE GWAS Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium. Genetic Correlation Between Amyotrophic Lateral Sclerosis and Schizophrenia. Nat Commun. 2017 Mar 21;8:14774. PMCID: PMC5364411. PMID: 28322246
Morgan AR, Touchard S, O'Hagan C, Sims R, Majounie E, Escott-Price V, Jones L, Williams J, Morgan BP. The Correlation Between Inflammatory Biomarkers and Polygenic Risk Score in Alzheimer's Disease. J Alzheimers Dis. 2017;56(1):25-36. DOI: 10.3233/JAD-160889. PMID: 27911318
Myrum C, Nikolaienko O, Bramham CR, Haavik J, Zayats T. Implication of the APP Gene in Intellectual Abilities. J Alzheimers Dis. 2017;59(2):723-735. PMCID: PMC5523840. PMID: 28671113
Larsson SC, Traylor M, Burgess S, Markus HS. Genetically-Predicted Adult Height and Alzheimer's Disease. J Alzheimers Dis. 2017;60(2):691-698. PMCID: PMC6037293. PMID: 28869480
Larsson SC, Traylor M, Burgess S, Markus HS. Genetically-Predicted Adult Height and Alzheimer's Disease. J Alzheimers Dis. 2017;60(2):691-698. PMCID: PMC6037293. PMID: 28869480
Lacour A, Espinosa A, Louwersheimer E, Heilmann S, Hernández I, Wolfsgruber S, Fernández V, Wagner H, Rosende-Roca M, Mauleón A, Moreno-Grau S, Vargas L, Pijnenburg YA, Koene T, Rodríguez-Gómez O, Ortega G, Ruiz S, Holstege H, Sotolongo-Grau O, Kornhuber J, Peters O, Frölich L, Hüll M, Rüther E, Wiltfang J, Scherer M, Riedel-Heller S, Alegret M, Nöthen MM, Scheltens P, Wagner M, Tárraga L, Jessen F, Boada M, Maier W, van der Flier WM, Becker T, Ramirez A, Ruiz A. Genome-wide Significant Risk Factors for Alzheimer's Disease: Role in Progression to Dementia due to Alzheimer's Disease Among Subjects with Mild Cognitive Impairment. Mol Psychiatry. 2017 Jan;22(1):153-160. PMCID: PMC5414086. PMID: 26976043
2016
Mokry LE, Ross S, Morris JA, Manousaki D, Forgetta V, Richards JB. Genetically Decreased Vitamin D and Risk of Alzheimer's Disease. Neurology. 2016 Dec 13;87(24):2567-2574. PMCID: PMC5207000. PMID: 27856775
Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beiser A, Bernard M, Bis JC, Blanken LM, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chauhan G, Chen Q, Ching CR, Cuellar-Partida G, Braber AD, Doan NT, Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman AL, Gottesman RF, Greven CU, Grimm O, Griswold ME, Guadalupe T, Hass J, Haukvik UK, Hilal S, Hofer E, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liao J, Liewald DC, Lopez LM, Luciano M, Macare C, Marquand A, Matarin M, Mather KA, Mattheisen M, Mazoyer B, McKay DR, McWhirter R, Milaneschi Y, Mirza-Schreiber N, Muetzel RL, Maniega SM, Nho K, Nugent AC, Loohuis LM, Oosterlaan J, Papmeyer M, Pappa I, Pirpamer L, Pudas S, Pütz B, Rajan KB, Ramasamy A, Richards JS, Risacher SL, Roiz-Santiañez R, Rommelse N, Rose EJ, Royle NA, Rundek T, Sämann PG, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Thomson R, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Vaidya D, Van der Grond J, Van der Meer D, Van Donkelaar MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Woldehawariat G, Wolf C, Wolfers T, Xu B, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Aggarwal NT, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Chen C, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Geus EJ, De Jager PL, de Zubicaray GI, Delanty N, Depondt C, DeStefano AL, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Erk S, Espeseth T, Evans DA, Fedko IO, Fernández G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Göring HH, Grabe HJ, Green RC, Gruber O, Gudnason V, Guelfi S, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Hulshoff Pol HE, Ikeda M, Ikram MK, Jack CR Jr, Jenkinson M, Johnson R, Jönsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaître H, Liu X, Longo DL, Longstreth WT Jr, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon KL, McMahon FJ, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Mühleisen TW, Müller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nöthen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schofield PR, Sigurdsson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Srikanth V, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Tiemeier H, Toga AW, Traynor BJ, Troncoso J, Turner JA, Tzourio C, Uitterlinden AG, Hernández MC, Van der Brug M, Van der Lugt A, Van der Wee NJ, Van Duijn CM, Van Haren NE, Van T Ent D, Van Tol MJ, Vardarajan BN, Veltman DJ, Vernooij MW, Völzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke HR, Zonderman AB, Deary IJ, DeCarli C, Schmidt H, Martin NG, De Craen AJ, Wright MJ, Launer LJ, Schumann G, Fornage M, Franke B, Debette S, Medland SE, Ikram MA, Thompson PM. Novel Genetic Loci Underlying Human Intracranial Volume Identified Through Genome-wide Association. Nat Neurosci. 2016 Dec;19(12):1569-1582. PMCID: PMC5227112.PMID: 27694991
Tosto G, Reitz C. Genomics of Alzheimer's Disease: Value of High-throughput Genomic Technologies to Dissect its Etiology. Mol Cell Probes. 2016 Dec;30(6):397-403. Epub 2016 Sep 13. Review. DOI: 10.1016/j.mcp.2016.09.001. PMID: 27618776
Srinivasan S, Bettella F, Mattingsdal M, Wang Y, Witoelar A, Schork AJ, Thompson WK, Zuber V; Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium, Winsvold BS, Zwart JA, Collier DA, Desikan RS, Melle I, Werge T, Dale AM, Djurovic S, Andreassen OA. Genetic Markers of Human Evolution Are Enriched in Schizophrenia. Biol Psychiatry. 2016 Aug 15;80(4):284-292. PMCID: PMC5397584. PMID: 26681495
Mormino EC, Sperling RA, Holmes AJ, Buckner RL, De Jager PL, Smoller JW, Sabuncu MR; Alzheimer's Disease Neuroimaging Initiative. Polygenic Risk of Alzheimer's disease is Associated with Early- and Late-life Processes. Neurology. 2016 Aug 2;87(5):481-8. PMCID: PMC4970660. PMID: 27385740
Zhang DF, Fan Y, Wang D, Bi R, Zhang C, Fang Y, Yao YG. PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses. Mol Neurobiol. 2016 Aug;53(6):4034-4045. PMCID: PMC26189833. PMID: 26189833
Chouraki V, Reitz C, Maury F, Bis JC, Bellenguez C, Yu L, Jakobsdottir J, Mukherjee S, Adams HH, Choi SH, Larson EB, Fitzpatrick A, Uitterlinden AG, de Jager PL, Hofman A, Gudnason V, Vardarajan B, Ibrahim-Verbaas C, van der Lee SJ, Lopez O, Dartigues JF, Berr C, Amouyel P, Bennett DA, van Duijn C, DeStefano AL, Launer LJ, Ikram MA, Crane PK, Lambert JC, Mayeux R, Seshadri S; International Genomics of Alzheimer’s Project. Evaluation of a Genetic Risk Score to Improved Risk Prediction for Alzheimer's Disease. J Alzheimers Dis. 2016 Jun 18;53(3):921-32. PMCID: PMC5036102. PMID: 27340842
Pickrell JK, Berisa T, Liu JZ, Ségurel L, Tung JY, Hinds DA. Detection and Interpretation of Shared Genetic Influences on 42 Human Traits. Nat Genet. 2016 Jul;48(7):709-17. Epub 2016 May 16. Erratum in: Nat Genet. 2016 Sep 28;48(10):1296. PMCID: PMC5207801. PMID: 27182965
Fryland T, Christensen JH, Pallesen J, Mattheisen M, Palmfeldt J, Bak M, Grove J, Demontis D, Blechingberg J, Ooi HS, Nyegaard M, Hauberg ME, Tommerup N, Gregersen N, Mors O, Corydon TJ, Nielsen AL, Børglum AD. Identification of the BRD1 Interaction Network and its Impact on Mental Disorder Risk. Genome Med. 2016 May 3;8(1):53. PMCID: PMC4855718. PMID: 27142060
Lupton MK, Strike L, Hansell NK, Wen W, Mather KA, Armstrong NJ, Thalamuthu A, McMahon KL, de Zubicaray GI, Assareh AA, Simmons A, Proitsi P, Powell JF, Montgomery GW, Hibar DP, Westman E, Tsolaki M, Kloszewska I, Soininen H, Mecocci P, Velas B, Lovestone S; Alzheimer's Disease Neuroimaging Initiative, Brodaty H, Ames D, Trollor JN, Martin NG, Thompson PM, Sachdev PS, Wright MJ. The Effect of Increased Genetic Risk for Alzheimer's Disease on Hippocampal and Amygdala Volume. Neurobiol Aging. 2016 Apr;40:68-77. PMCID: PMC4883003. PMID: 26973105
Traylor M, Adib-Samii P, Harold D; Alzheimer's Disease Neuroimaging Initiative; International Stroke Genetics Consortium (ISGC), UK Young Lacunar Stroke DNA resource, Dichgans M, Williams J, Lewis CM, Markus HS; METASTROKE; International Genomics of Alzheimer's Project (IGAP), investigators. Shared Genetic Contribution to Ischaemic Stroke and Alzheimer's Disease. Ann Neurol. 2016 Feb 23. PMCID: PMC4864940. PMID: 26913989
Walter S, Marden JR, Kubzansky LD, Mayeda ER, Crane PK, Chang SC, Cornelis M, Rehkopf DH, Mukherjee S, Glymour MM. Diabetic Phenotypes and Late-Life Dementia Risk: A Mechanism-specific Mendelian Randomization Study. Alzheimer Dis Assoc Disord. 2016 Jan-Mar;30(1):15-20. PMCID: PMC4879683. PMID: 26650880
2015
Heck A, Fastenrath M, Coynel D, Auschra B, Bickel H, Freytag V, Gschwind L, Hartmann F, Jessen F, Kaduszkiewicz H, Maier W, Milnik A, Pentzek M, Riedel-Heller SG, Spalek K, Vogler C, Wagner M, Weyerer S, Wolfsgruber S, de Quervain DJ, Papassotiropoulos A. Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease. JAMA Psychiatry. 2015 Oct;72(10):1029-36. PMCID: PMC5291164. PMID: 26332608
Allen M, Kachadoorian M, Carrasquillo MM, Karhade A, Manly L, Burgess JD, Wang C, Serie D, Wang X, Siuda J, Zou F, Chai HS, Younkin C, Crook J, Medway C, Nguyen T, Ma L, Malphrus K, Lincoln S, Petersen RC, Graff-Radford NR, Asmann YW, Dickson DW, Younkin SG, Ertekin-Taner N. Late-onset Alzheimer Disease Risk variants mark brain regulatory loci. Neurol Genet. 2015 Jul 23;1(2):e15. PMCID: PMC4807909. PMID: 27066552
2014
Hinney A, Albayrak O, Antel J, Volckmar AL, Sims R, Chapman J, Harold D, Gerrish A, Heid IM, Winkler TW, Scherag A, Wiltfang J, Williams J, Hebebrand J; GERAD Consortium; IGAP Consortium; GIANT Consortium. Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity. Am J Med Genet B Neuropsychiatr Genet. 2014 Jun;165B(4):283-93. PMCID: PMC4879683. PMID: 24788522