ADGC Publications

Found 65 results
Filters: Keyword is Genetic Predisposition to Disease  [Clear All Filters]
2016
Karch CM, Ezerskiy LA, Bertelsen S, Goate AM.  2016.  Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.. PLoS One. 11(2):e0148717.
Mez J, Mukherjee S, Thornton T, Fardo DW, Trittschuh E, Sutti S, Sherva R, Kauwe JS, Naj AC, Beecham GW et al..  2016.  The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable.. Neurobiol Aging. 41:115-121.
Kunkle BW, Jaworski J, Barral S, Vardarajan B, Beecham GW, Martin ER, Cantwell LS, Partch A, Bird TD, Raskind WH et al..  2016.  Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease.. Alzheimers Dement. 12(1):2-10.
Tosto G, Reitz C.  2016.  Genomics of Alzheimer's disease: Value of high-throughput genomic technologies to dissect its etiology.. Mol Cell Probes. 30(6):397-403.
Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML et al..  2016.  Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.. Alzheimers Dement. 12(3):233-43.
Ebbert MTW, Boehme KL, Wadsworth ME, Staley LA, Mukherjee S, Crane PK, Ridge PG, Kauwe JSK.  2016.  Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk.. Alzheimers Dement. 12(2):121-129.
2015
Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JRB, Boehme KL, Walter S, Kauwe JS et al..  2015.  Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.. PLoS Med. 12(6):e1001841;discussione1001841.
Escott-Price V, Sims R, Bannister C, Harold D, Vronskaya M, Majounie E, Badarinarayan N, Morgan K, Passmore P, Holmes C et al..  2015.  Common polygenic variation enhances risk prediction for Alzheimer's disease.. Brain. 138(Pt 12):3673-84.
International Genomics of Alzheimer's Disease Consortium (IGAP).  2015.  Convergent genetic and expression data implicate immunity in Alzheimer's disease.. Alzheimers Dement. 11(6):658-71.
Malik M, Chiles J, Xi HS, Medway C, Simpson J, Potluri S, Howard D, Liang Y, Paumi CM, Mukherjee S et al..  2015.  Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia.. Hum Mol Genet. 24(12):3557-70.
Barral S, Cheng R, Reitz C, Vardarajan B, Lee J, Kunkle B, Beecham G, Cantwell LS, Pericak-Vance MA, Farrer LA et al..  2015.  Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease.. Alzheimers Dement. 11(12):1397-1406.
Nelson PT, Wang W-X, Partch AB, Monsell SE, Valladares O, Ellingson SR, Wilfred BR, Naj AC, Wang L-S, Kukull WA et al..  2015.  Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology.. J Neuropathol Exp Neurol. 74(1):75-84.
2014
Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YSon, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang L-S et al..  2014.  Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.. JAMA Neurol. 71(11):1394-404.
Samocha KE, Robinson EB, Sanders SJ, Stevens C, Sabo A, McGrath LM, Kosmicki JA, Rehnström K, Mallick S, Kirby A et al..  2014.  A framework for the interpretation of de novo mutation in human disease.. Nat Genet. 46(9):944-50.
Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel J-P, Younkin SG et al..  2014.  Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.. PLoS Genet. 10(9):e1004606.
Jun G, Asai H, Zeldich E, Drapeau E, Chen CD, Chung J, Park J-H, Kim S, Haroutunian V, Foroud T et al..  2014.  PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.. Ann Neurol. 76(3):379-92.
Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W et al..  2014.  A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.. Nat Med. 20(12):1452-7.
Logue MW, Schu M, Vardarajan BN, Farrell J, Lunetta KL, Jun G, Baldwin CT, Deangelis MM, Farrer LA.  2014.  Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways.. Neurobiol Aging. 35(6):1510.e7-18.
Logue MW, Schu M, Vardarajan BN, Farrell J, Bennett DA, Buxbaum JD, Byrd GS, Ertekin-Taner N, Evans D, Foroud T et al..  2014.  Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans.. Alzheimers Dement. 10(6):609-618.e11.
2013
Nuytemans K, Bademci G, Kohli MM, Beecham GW, Wang L-S, Young JI, Nahab F, Martin ER, Gilbert JR, Benatar M et al..  2013.  C9ORF72 intermediate repeat copies are a significant risk factor for Parkinson disease.. Ann Hum Genet. 77(5):351-63.
Hibar DP, Stein JL, Ryles AB, Kohannim O, Jahanshad N, Medland SE, Hansell NK, McMahon KL, de Zubicaray GI, Montgomery GW et al..  2013.  Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.. Brain Imaging Behav. 7(2):102-15.
Reitz C, Tosto G, Vardarajan B, Rogaeva E, Ghani M, Rogers RS, Conrad C, Haines JL, Pericak-Vance MA, Fallin MD et al..  2013.  Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP).. Transl Psychiatry. 3:e256.
Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B et al..  2013.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.. Nat Genet. 45(12):1452-8.
Kohli MA, John-Williams K, Rajbhandary R, Naj A, Whitehead P, Hamilton K, Carney RM, Wright C, Crocco E, Gwirtzman HE et al..  2013.  Repeat expansions in the C9ORF72 gene contribute to Alzheimer's disease in Caucasians.. Neurobiol Aging. 34(5):1519.e5-12.
Stutzbach LD, Xie SX, Naj AC, Albin R, Gilman S, M Y Lee V, Trojanowski JQ, Devlin B, Schellenberg GD.  2013.  The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease.. Acta Neuropathol Commun. 1:31.

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