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Title | Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Andrews SJ, Goate A, Anstey KJ |
Journal | Alzheimers Dement |
Volume | 16 |
Issue | 2 |
Pagination | 345-353 |
Date Published | 02/2020 |
ISSN | 1552-5279 |
Abstract | INTRODUCTION: Observational studies have suggested that light-to-moderate alcohol consumption decreases the risk of Alzheimer's disease, but it is unclear if this association is causal. METHODS: Two-sample Mendelian randomization (MR) analysis was used to examine whether alcohol consumption, alcohol dependence, or Alcohol Use Disorder Identification Test (AUDIT) scores were causally associated with the risk of Late-Onset Alzheimer's disease (LOAD) or Alzheimer's disease age of onset survival (AAOS). Additionally, γ-glutamyltransferase levels were included as a positive control. RESULTS: There was no evidence of a causal association between alcohol consumption, alcohol dependence, or AUDIT, and LOAD. Alcohol consumption was associated with an earlier AAOS and increased γ-glutamyltransferase blood concentrations. Alcohol dependence was associated with a delayed AAOS. DISCUSSION: MR found robust evidence of a causal association between alcohol consumption and an earlier AAOS, but not alcohol intake and LOAD risk. The protective effect of alcohol dependence is potentially due to survivor bias. |
DOI | 10.1016/j.jalz.2019.09.086 |
Alternate Journal | Alzheimers Dement |
PubMed ID | 31786126 |
PubMed Central ID | PMC7057166 |
Grant List | 1002560 / / NHMRC / International 503480 / MRC_ / Medical Research Council / United Kingdom U24 AG021886 / AG / NIA NIH HHS / United States U01 AG032984 / AG / NIA NIH HHS / United States / / Erasmus University Rotterdam / International / / Federal Ministry of Education and Research / International 503176 / / Alzheimer's Research UK / International R01 HL105756 / HL / NHLBI NIH HHS / United States / / Icelandic Heart Association / International / / Erasmus Medical Center / International U10 AA008401 / AA / NIAAA NIH HHS / United States / / JPB Foundation / International U01 AG016976 / AG / NIA NIH HHS / United States R01 AG033193 / AG / NIA NIH HHS / United States / / Institut Pasteur / International 082604/2/07/Z / WT_ / Wellcome Trust / United Kingdom ADGC-10-196728 / / Alzheimer's Association / International / / Inserm / International AG081220 / AG / NIA NIH HHS / United States / WT_ / Wellcome Trust / United Kingdom |