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Title | A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Toledo JB, Van Deerlin VM, Lee EB, Suh ER, Baek Y, Robinson JL, Xie SX, McBride J, Wood EM, Schuck T, Irwin DJ, Gross RG, Hurtig H, McCluskey L, Elman L, Karlawish J, Schellenberg G, Chen-Plotkin A, Wolk D, Grossman M, Arnold SE, Shaw LM, Lee VM-Y, Trojanowski JQ |
Journal | Alzheimers Dement |
Volume | 10 |
Issue | 4 |
Pagination | 477-484.e1 |
Date Published | 2014 Jul |
ISSN | 1552-5279 |
Keywords | Amyloid beta-Peptides, Biological Specimen Banks, Central Nervous System, Databases, Factual, Female, Genotype, Hospitals, University, Humans, Male, Neurodegenerative Diseases, Pennsylvania, tau Proteins |
Abstract | Neurodegenerative diseases (NDs) are defined by the accumulation of abnormal protein deposits in the central nervous system (CNS), and only neuropathological examination enables a definitive diagnosis. Brain banks and their associated scientific programs have shaped the actual knowledge of NDs, identifying and characterizing the CNS deposits that define new diseases, formulating staging schemes, and establishing correlations between neuropathological changes and clinical features. However, brain banks have evolved to accommodate the banking of biofluids as well as DNA and RNA samples. Moreover, the value of biobanks is greatly enhanced if they link all the multidimensional clinical and laboratory information of each case, which is accomplished, optimally, using systematic and standardized operating procedures, and in the framework of multidisciplinary teams with the support of a flexible and user-friendly database system that facilitates the sharing of information of all the teams in the network. We describe a biobanking system that is a platform for discovery research at the Center for Neurodegenerative Disease Research at the University of Pennsylvania. |
DOI | 10.1016/j.jalz.2013.06.003 |
Alternate Journal | Alzheimers Dement |
PubMed ID | 23978324 |
PubMed Central ID | PMC3933464 |
Grant List | R01 NS044266 / NS / NINDS NIH HHS / United States P30 AG010124 / AG / NIA NIH HHS / United States R01 AG015116 / AG / NIA NIH HHS / United States NS053488 / NS / NINDS NIH HHS / United States AG10124 / AG / NIA NIH HHS / United States NS44266 / NS / NINDS NIH HHS / United States P01 AG017586 / AG / NIA NIH HHS / United States T32 AG000255 / AG / NIA NIH HHS / United States AG15116 / AG / NIA NIH HHS / United States K08 AG039510 / AG / NIA NIH HHS / United States P50 NS053488 / NS / NINDS NIH HHS / United States AG17586 / AG / NIA NIH HHS / United States AG033101 / AG / NIA NIH HHS / United States K08 AG033101 / AG / NIA NIH HHS / United States U01 NS082134 / NS / NINDS NIH HHS / United States K23 NS088341 / NS / NINDS NIH HHS / United States AG39510 / AG / NIA NIH HHS / United States |