Bias in parameter estimates due to omitting gene-environment interaction terms in case-control studies.

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TitleBias in parameter estimates due to omitting gene-environment interaction terms in case-control studies.
Publication TypeJournal Article
Year of Publication2018
AuthorsLobach I
JournalGenet Epidemiol
Volume42
Issue8
Pagination838-845
Date Published2018 12
ISSN1098-2272
Abstract

Genetic studies are continuing to generate volumes and variety of data that can be used to examine the genetic effects. Often the effect of a genetic variant varies by nongenetic measures, what is traditionally defined as gene-environment interaction (G×E). If the G×E term is neglected, estimates of the main effects can be substantially biased. We derive a general and convenient approximation to the magnitude of bias in the estimates due to omitting the G×E term. We show that the approximation is reasonably accurate in finite samples. We then apply the approximation in a study of Alzheimer's disease.
DOI10.1002/gepi.22154
Alternate JournalGenet. Epidemiol.
PubMed ID30302820
PubMed Central IDPMC6239944
Grant ListRC2 AG036528 / AG / NIA NIH HHS / United States
U24 AG021886 / AG / NIA NIH HHS / United States
U01 AG032984 / AG / NIA NIH HHS / United States
U01 AG016976 / AG / NIA NIH HHS / United States
R21 AG043710 / AG / NIA NIH HHS / United States
U24 AG041689 / AG / NIA NIH HHS / United States
5R21AG043710-02 / NH / NIH HHS / United States