ABCB1 genotype and CSF beta-amyloid in Alzheimer disease.

TitleABCB1 genotype and CSF beta-amyloid in Alzheimer disease.
Publication TypeJournal Article
Year of Publication2011
AuthorsKohen R, Shofer JB, Korvatska O, Petrie EC, Wang LY, Schellenberg GD, Peskind ER, Wilkinson CW
JournalJ Geriatr Psychiatry Neurol
Volume24
Issue2
Pagination63-6
Date Published2011 Jun
ISSN0891-9887
KeywordsAged, Alleles, Alzheimer Disease, Amyloid beta-Peptides, ATP Binding Cassette Transporter, Subfamily B, ATP Binding Cassette Transporter, Subfamily B, Member 1, Female, Gene Frequency, Genetic Association Studies, Humans, Linear Models, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide
Abstract

The ABCB1 gene, coding for the efflux transporter P-glycoprotein (PGP), is a candidate gene for Alzheimer disease (AD). P-glycoprotein is heavily expressed at the blood-brain barrier, where it mediates the efflux of β-amyloid (Aβ) from the brain. In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of Aβ. No strong evidence for association was found.
DOI10.1177/0891988711402325
Alternate JournalJ Geriatr Psychiatry Neurol
PubMed ID21478475
PubMed Central IDPMC3293495
Grant ListK08 AG023670 / AG / NIA NIH HHS / United States
P50 AG005136 / AG / NIA NIH HHS / United States
P50 AG005136-16 / AG / NIA NIH HHS / United States
P50AG005136 / AG / NIA NIH HHS / United States