ADGC Publications

Found 248 results
2022
Chung J, Das A, Sun X, Sobreira DR, Leung YYee, Igartua C, Mozaffari S, Chou Y-F, Thiagalingam S, Mez J et al..  2022.  Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women.. Alzheimers Dement.
Shade LMp, Katsumata Y, Hohman TJ, Nho K, Saykin AJ, Mukherjee S, Boehme KL, Kauwe JSk, Farrer LA, Schellenberg GD et al..  2022.  Genome-wide association study of brain arteriolosclerosis.. J Cereb Blood Flow Metab. 42(8):1437-1450.
Rajabli F, Beecham GW, Hendrie HC, Baiyewu O, Ogunniyi A, Gao S, Kushch NA, Lipkin-Vasquez M, Hamilton-Nelson KL, Young JI et al..  2022.  A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry.. PLoS Genet. 18(7):e1009977.
Heath L, Earls JC, Magis AT, Kornilov SA, Lovejoy JC, Funk CC, Rappaport N, Logsdon BA, Mangravite LM, Kunkle BW et al..  2022.  Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90.. Sci Rep. 12(1):6117.
Romero-Molina C, Garretti F, Andrews SJ, Marcora E, Goate AM.  2022.  Microglial efferocytosis: Diving into the Alzheimer's disease gene pool.. Neuron. 110(21):3513-3533.
Katsumata Y, Shade LM, Hohman TJ, Schneider JA, Bennett DA, Farfel JM, Kukull WA, Fardo DW, Nelson PT.  2022.  Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities.. Neurobiol Dis. 174:105880.
Godrich D, Martin ER, Schellenberg G, Pericak-Vance MA, Cuccaro M, Scott WK, Kukull W, Montine T, Beecham GW.  2022.  Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population.. Alzheimers Dement. 18(12):2403-2412.
Vardarajan BN, Reyes-Dumeyer D, Piriz AL, Lantigua RA, Medrano M, Rivera D, Jimenez-Velazquez IZ, Martin E, Pericak-Vance MA, Bush W et al..  2022.  Progranulin mutations in clinical and neuropathological Alzheimer's disease.. Alzheimers Dement. 18(12):2458-2467.
Jun GR, You Y, Zhu C, Meng G, Chung J, Panitch R, Hu J, Xia W, Bennett DA, Foroud TM et al..  2022.  Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease.. Alzheimers Dement. 18(11):2042-2054.
Wang H, San Wang L-, Schellenberg G, Lee W-P.  2022.  The role of structural variations in Alzheimer's disease and other neurodegenerative diseases.. Front Aging Neurosci. 14:1073905.
Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi SEun, Bush WS, Engelman CD et al..  2022.  Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.. Brain. 145(7):2541-2554.
2021
Zhang X, Farrell JJ, Tong T, Hu J, Zhu C, San Wang L-, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD et al..  2021.  Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease.. Alzheimers Dement.
Chen H-H, Petty LE, Sha J, Zhao Y, Kuzma A, Valladares O, Bush W, Naj AC, Gamazon ER, Below JE.  2021.  Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci.. Transl Psychiatry. 11(1):618.
DeMichele-Sweet MAnn A, Klei L, Creese B, Harwood JC, Weamer EA, McClain L, Sims R, Hernández I, Moreno-Grau S, Tárraga L et al..  2021.  Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease.. Mol Psychiatry.
Gao Y, Felsky D, Reyes-Dumeyer D, Sariya S, Rentería MArce, Ma Y, Klein H-U, Cosentino S, De Jager PL, Bennett DA et al..  2021.  Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance.. Alzheimers Dementia.
Kunkle BW, Schmidt M, Klein H-U, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD et al..  2021.  Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.. JAMA Neurol. 78(1):102-113.
Huq AJ, Fulton-Howard B, Riaz M, Laws S, Sebra R, Ryan J, Renton AE, Goate AM, Masters CL, Storey E et al..  2021.  Polygenic score modifies risk for Alzheimer's disease in ε4 homozygotes at phenotypic extremes.. Alzheimers Dement (Amst). 13(1):e12226.
Palmer SC, Tendal B, Mustafa RA, Vandvik POlav, Li S, Hao Q, Tunnicliffe D, Ruospo M, Natale P, Saglimbene V et al..  2021.  Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials.. BMJ. 372:m4573.
2020
Andrews SJ, Goate A, Anstey KJ.  2020.  Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study.. Alzheimers Dement. 16(2):345-353.
van der Meer D, Sønderby IE, Kaufmann T, G Walters B, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M et al..  2020.  Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition.. JAMA Psychiatry. 77(4):420-430.
Ouellette AR, Neuner SM, Dumitrescu L, Anderson LC, Gatti DM, Mahoney ER, Bubier JA, Churchill G, Peters L, Huentelman MJ et al..  2020.  Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia.. Cell Rep. 32(9):108091.
Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J et al..  2020.  Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.. Nat Commun. 11(1):667.
Vance E, Murcia JDGonzalez, Miller JB, Staley L, Crane PK, Mukherjee S, Kauwe JSK.  2020.  Failure to detect synergy between variants in transferrin and hemochromatosis and Alzheimer's disease in large cohort.. Neurobiol Aging. 89:142.e9-142.e12.
Dumitrescu L, Mahoney ER, Mukherjee S, Lee ML, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J et al..  2020.  Genetic variants and functional pathways associated with resilience to Alzheimer's disease.. Brain. 143(8):2561-2575.
Sherva R, Gross A, Mukherjee S, Koesterer R, Amouyel P, Bellenguez C, Dufouil C, Bennett DA, Chibnik L, Cruchaga C et al..  2020.  Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways.. Alzheimers Dement. 16(8):1134-1145.

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